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Effects of cysteamine on pro-somatostatin related peptides.

作者信息

Bakhit C, Benoit R, Bloom F E

出版信息

Regul Pept. 1983 May;6(2):169-77. doi: 10.1016/0167-0115(83)90010-1.

DOI:10.1016/0167-0115(83)90010-1
PMID:6192467
Abstract

Intracerebroventricular (icv) injection of cysteamine to rats produced a marked depletion of somatostatin-14-like immunoreactivity (LI) in all rat brain regions examined. The somatostatin-28 (SS28)-LI and SS28(1-12)-LI were generally not altered by the cysteamine treatment. Following subcutaneous injection of the drug similar depletions of hypothalamic SS14-LI was observed with no change in SS28-LI nor SS28(1-12)-LI. In vitro cysteamine significantly increased the basal release of SS14-LI and markedly potentiated the evoked release of SS14-LI from hypothalamic slices. At 10 mM cysteamine, enhanced release of SS14-LI from hypothalamic slices was still observed despite a marked depletion of tissue content of SS14-LI.

摘要

相似文献

1
Effects of cysteamine on pro-somatostatin related peptides.
Regul Pept. 1983 May;6(2):169-77. doi: 10.1016/0167-0115(83)90010-1.
2
Evidence for selective release of somatostatin-14 and somatostatin-28(1-12) from rat hypothalamus.大鼠下丘脑选择性释放生长抑素-14和生长抑素-28(1-12)的证据。
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Somatostatin and SMS 201-995 reverse the impairment of cognitive functions induced by cysteamine depletion of brain somatostatin.生长抑素和SMS 201-995可逆转由半胱胺耗竭脑内生长抑素所引起的认知功能损害。
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Cysteamine-induced depletion of brain somatostatin is associated with up-regulation of cerebrocortical somatostatin receptors.半胱胺诱导的脑内生长抑素耗竭与大脑皮质生长抑素受体上调有关。
Endocrinology. 1984 Sep;115(3):990-5. doi: 10.1210/endo-115-3-990.

引用本文的文献

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Role of somatostatin in regulation of insular-acinar axis.
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