Morinaga S, Ojima M, Sasano N
Cancer. 1983 Oct 1;52(7):1281-9. doi: 10.1002/1097-0142(19831001)52:7<1281::aid-cncr2820520725>3.0.co;2-9.
The relation between immunohistochemical demonstration and tissue concentration of humanchorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) was examined in 17 testicular germ cell tumors. There was a good correlation between their results; e.g., a tumor with high hCG concentration contained numerous hCG positive cells, and vice versa. The immunoperoxidase localization of hCG and AFP was investigated in 57 tumors including above 17. HCG was revealed in syncytiotrophoblastic giant cells of seminoma or embryonal carcinoma as well as syncytial cells of choriocarcinoma, and on rare occasion in mononuclear cells. AFP was localized in tumor cells of yolk sac tumor or embryonal carcinoma and occasionally hyaline globules. No cell was stained concomitantly with hCG and AFP. Pathogenetical significance of cells positively stained was discussed.
在17例睾丸生殖细胞肿瘤中研究了人绒毛膜促性腺激素（hCG）和甲胎蛋白（AFP）的免疫组织化学显示与组织浓度之间的关系。它们的结果之间存在良好的相关性；例如，hCG浓度高的肿瘤含有大量hCG阳性细胞，反之亦然。在包括上述17例在内的57例肿瘤中研究了hCG和AFP的免疫过氧化物酶定位。在精原细胞瘤或胚胎癌的合体滋养层巨细胞以及绒毛膜癌的合体细胞中发现了hCG，在极少数情况下在单核细胞中也有发现。AFP定位于卵黄囊瘤或胚胎癌的肿瘤细胞以及偶尔的透明小球中。没有细胞同时被hCG和AFP染色。讨论了阳性染色细胞的发病学意义。
