Butcher D N, Gregory W M, Gunter P A, Masters J R, Parkinson M C
Br J Cancer. 1985 Apr;51(4):473-8. doi: 10.1038/bjc.1985.68.
The morphological appearance, incidence and prognostic significance of human chorionic gonadotrophin (HCG)-containing cells in seminomas were examined in a retrospective series of 228 orchidectomy specimens, obtained between 1958 and 1972. Sections from each tumour were stained with haematoxylin and eosin (H & E) and immunocytochemically for HCG. In 33 (14.5%) of the tumours HCG-containing cells were observed, but in only 12 were these recognised in an initial study of the H & E stained sections. HCG staining was seen predominantly in syncytiotrophoblastic giant cells and rarely in "mulberry" cells and mononuclear seminoma cells. Of the patients whose tumours included HCG-containing cells 23% died of their disease within 2 years of orchidectomy, compared with only 8% of the patients whose tumours lacked this feature. It is concluded that immunocytochemical staining for HCG should form part of the routine histological assessment of seminomas, and that the presence of HCG-containing cells indicates a more aggressive disease.
对1958年至1972年间获取的228例睾丸切除标本进行回顾性研究，以检查精原细胞瘤中含人绒毛膜促性腺激素（HCG）细胞的形态学表现、发生率及预后意义。对每个肿瘤的切片进行苏木精和伊红（H&E）染色以及HCG免疫细胞化学染色。在33例（14.5%）肿瘤中观察到含HCG细胞，但在对H&E染色切片的初步研究中仅识别出12例。HCG染色主要见于合体滋养层巨细胞，很少见于“桑葚”细胞和单核精原细胞瘤细胞。肿瘤中含有HCG细胞的患者，23%在睾丸切除术后2年内死于该病，而肿瘤缺乏此特征的患者仅8%。结论是，HCG免疫细胞化学染色应成为精原细胞瘤常规组织学评估的一部分，且含HCG细胞的存在表明疾病更具侵袭性。
