乳糜泻主要与一个DC基因座等位基因特异性相关的证据。
Evidence that celiac disease is primarily associated with a DC locus allelic specificity.
作者信息
Tosi R, Vismara D, Tanigaki N, Ferrara G B, Cicimarra F, Buffolano W, Follo D, Auricchio S
出版信息
Clin Immunol Immunopathol. 1983 Sep;28(3):395-404. doi: 10.1016/0090-1229(83)90106-x.
PMID:6192959
Abstract
Sixty patients with celiac disease were typed by radioimmunoassay for the specificities HLA-DR3, HLA-DR7, and for an allelic specificity, DC3, of the HLA-associated DC locus. We found that celiac disease is primarily associated with the DC determinant. The previously described associations with DR3, DR7, B8, B13, and A1 can be explained by decreasing degrees of linkage disequilibrium with DC3.
摘要
采用放射免疫分析法对60例乳糜泻患者进行HLA-DR3、HLA-DR7特异性分型以及HLA相关DC位点的等位基因特异性DC3分型。我们发现乳糜泻主要与DC决定簇相关。先前描述的与DR3、DR7、B8、B13和A1的关联可以用与DC3连锁不平衡程度的降低来解释。
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