[头颈部鳞状细胞癌患者化疗研究的2期中期评估。两种治疗方案的比较：顺二氯二氨铂（II）和博来霉素与甲氨蝶呤和长春地辛]

[2d interim evaluation of a chemotherapy study on patients with squamous cell carcinomas of the head-neck area. A comparison of 2 therapy regimens: cis-diamminedichloroplatinum (II) and bleomycin versus methotrexate and vindesine].

作者信息

Schröder M, von Heyden H W, Scherpe A, Borghardt J, Beyer J H, Nagel G A, Gerhartz H, Kastenbauer E, Westerhausen M, Schroeder M, Caliebe W, Rudert H, Lissers R, Hofmann J, Schneider B

出版信息

Onkologie. 1983 Jun;6(3):114-7. doi: 10.1159/000215214.

DOI:10.1159/000215214

PMID:6193472

Abstract

52 patients with epidermoid cancer of the head and neck region were either treated with cis-DDP and bleomycin (arm A) or with methotrexate and vindesine (arm B). In case of resistance patients were further treated with the alternative regimen (A leads to B or B leads to A). Treatment results are superior in arm A. Complete and partial remission were in A: 54%, in B: 31%, after crossover 46% and 0%, respectively. Status of pretreatment (operation and/or radiotherapy) is of minor importance for arm A than for the "soft" treatment of arm B. Preliminary analysis of survival and remission duration shows no significant difference in regard to A or B and status of pretreatment. However, those patients resistant to B and further treated with A have an increase of median survival from 3 to 9 months (p = 0.02). With primary chemotherapy inoperable tumors can be made operable with curative intention.

摘要

52例头颈部表皮样癌患者，一部分接受顺铂和博来霉素治疗（A组），另一部分接受甲氨蝶呤和长春地辛治疗（B组）。若出现耐药，患者改用替代方案治疗（A组转B组或B组转A组）。A组治疗效果更佳。完全缓解和部分缓解率在A组为54%，B组为31%，交叉治疗后分别为46%和0%。与B组的“温和”治疗相比，预处理状态（手术和/或放疗）对A组的重要性较低。生存和缓解期的初步分析显示，A组或B组以及预处理状态方面无显著差异。然而，那些对B组耐药并改用A组治疗的患者，中位生存期从3个月增至9个月（p = 0.02）。通过初始化疗，无法手术的肿瘤可转变为可进行根治性手术切除的肿瘤。