Finley J M, Acland R D, Wood M B
Plast Reconstr Surg. 1978 Jan;61(1):1-6. doi: 10.1097/00006534-197801000-00001.
Rib periosteum was transplanted to the groins of 9 dogs. In half of the periosteal grafts, no microvascular anastomoses were done (free grafts); at 6 weeks after grafting they had become resorbed. The other periosteal grafts were revascularized by microvascular anastomoses of the intercostal vessels to local muscular vessels; at 6 weeks those with confirmed vascular patency had all formed substantial amounts of new bone. Five cm, full-thickness defects were created in the tibias of 10 dogs. The control animals (without grafting) did not heal in two months. However, the experimental dogs, with vascularized periosteal grafts in the defects regenerated their tibias with healthy new bone by 6 weeks--and were walking on them then.
将肋骨骨膜移植到9只狗的腹股沟处。在一半的骨膜移植物中，未进行微血管吻合（游离移植物）；移植后6周，它们已被吸收。另一半骨膜移植物通过肋间血管与局部肌肉血管的微血管吻合进行血管重建；6周时，血管通畅得到确认的那些移植物均已形成大量新骨。在10只狗的胫骨上制造了5厘米的全层缺损。对照动物（未进行移植）在两个月内未愈合。然而，实验狗在缺损处植入带血管蒂的骨膜移植物后，6周时胫骨用健康的新骨再生——然后它们就能用这些胫骨行走了。
