Gutstein H S, Cohen S R
Science. 1978 Jan 20;199(4326):301-3. doi: 10.1126/science.619457.
The spinal fluid of sheep with experimental allergic encephalomyelitis contains myelin basic protein (6 to 18 nanograms per milliliter) bound to antibody as well as excess free antibody. This bound myelin basic protein appeared concurrently with the onset of the disease and remained elevated until death. In contrast, in active multiple sclerosis, the spinal fluid contains free myelin basic protein and there are no detectable levels of antibody. The results indicate that the antibodies enter the spinal fluid from the serum by passive diffusion. This mechanism may also explain the presence of viral antibodies in the spinal fluid of multiple sclerosis patients.
患有实验性变应性脑脊髓炎的绵羊的脑脊液中含有与抗体结合的髓鞘碱性蛋白（每毫升6至18纳克）以及过量的游离抗体。这种结合的髓鞘碱性蛋白在疾病发作时同时出现，并一直升高直至死亡。相比之下，在活动性多发性硬化症中，脑脊液中含有游离的髓鞘碱性蛋白，且检测不到抗体水平。结果表明，抗体通过被动扩散从血清进入脑脊液。这种机制也可能解释了多发性硬化症患者脑脊液中病毒抗体的存在。
