多发性硬化症患者血清和脑脊液中抗髓鞘碱性蛋白抗体及其IgG亚类分布
Serum and cerebrospinal fluid antibodies against myelin basic protein and their IgG subclass distribution in multiple sclerosis.
作者信息
García-Merino A, Persson M A, Ernerudh J, Díaz-Gil J J, Olsson T
出版信息
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1066-70. doi: 10.1136/jnnp.49.9.1066.
Abstract
IgG class antibodies reactive with myelin basic protein (MBP) were determined by enzyme-linked immunosorbent assay (ELISA) in serum and cerebrospinal fluid (CSF) of 37 patients with multiple sclerosis and a control group of 32 patients with tension headache or psychoneurosis. Using standardised amounts of IgG from CSF and serum in ELISA, significantly higher mean antibody levels were found in CSF as well as in serum from the patients with multiple sclerosis. Ten (27%) of the multiple sclerosis CSF samples and 15 (41%) of the multiple sclerosis sera revealed anti MBP antibody levels exceeding 2 SD of the control group. Seven patients (19%) showed exclusive or higher levels of anti MBP antibodies in CSF, suggesting synthesis within the central nervous system. Analysis by ELISA for IgG subclasses of anti MBP antibodies revealed that they were restricted to IgG 1 in four patients and IgG 3 in one.
摘要
通过酶联免疫吸附测定（ELISA）测定了37例多发性硬化症患者以及32例紧张性头痛或精神神经症患者组成的对照组的血清和脑脊液（CSF）中与髓鞘碱性蛋白（MBP）反应的IgG类抗体。在ELISA中使用标准化量的脑脊液和血清中的IgG，发现多发性硬化症患者的脑脊液和血清中的平均抗体水平明显更高。10份（27%）多发性硬化症脑脊液样本和15份（41%）多发性硬化症血清显示抗MBP抗体水平超过对照组的2个标准差。7例患者（19%）脑脊液中显示出单独的或更高水平的抗MBP抗体，提示在中枢神经系统内合成。通过ELISA分析抗MBP抗体的IgG亚类，发现4例患者的抗体限于IgG 1，1例限于IgG 3。
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