Fera G, Frappampina V, Baldi L, Schiraldi O
Boll Soc Ital Biol Sper. 1983 Jul 30;59(7):909-13.
In order to evaluate the immunomodulating activity of isoprinosine in chronic infections, 7 patients with chronic brucellosis unresponsive to antibiotic and corticosteroid therapy were treated with 4 g/die of isoprinosine in association with antibiotic therapy from 3 to 6 months. Immunoserologic and clinical evaluation were obtained at regular intervals from each patient. The treatment induced a significant increase of E rosette formation, reduction of erythrocyte sedimentation rate, associated with improvement or disappearance of clinical symptoms. These data suggest that isoprinosine may favourably influence the clinical course of chronic brucellosis, probably modifying host cell-mediated immune response.
为了评估异丙肌苷在慢性感染中的免疫调节活性，7例对抗生素和皮质类固醇治疗无反应的慢性布鲁氏菌病患者，在抗生素治疗的同时，接受每日4g异丙肌苷治疗，疗程为3至6个月。定期对每位患者进行免疫血清学和临床评估。治疗后E玫瑰花结形成显著增加，红细胞沉降率降低，同时临床症状改善或消失。这些数据表明，异丙肌苷可能对慢性布鲁氏菌病的临床病程产生有利影响，可能是通过改变宿主细胞介导的免疫反应来实现的。
