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1
Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen.经刺激的T细胞系的培养上清液具有辅助活性，该活性在B细胞对抗原的应答中与白细胞介素2协同发挥作用。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2517-21. doi: 10.1073/pnas.78.4.2517.
2
B cell helper factors. II. Synergy among three helper factors in the response of T cell- and macrophage-depleted B cells.B细胞辅助因子。II. 三种辅助因子在T细胞和巨噬细胞缺陷的B细胞应答中的协同作用。
J Immunol. 1982 Oct;129(4):1398-402.
3
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.白细胞介素5，一种由T细胞产生的B细胞分化因子，也可诱导细胞毒性T淋巴细胞。
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4234-8. doi: 10.1073/pnas.84.12.4234.
4
T cell-replacing factor in specific antibody responses to influenza virus by human blood B cells.人血B细胞对流感病毒特异性抗体反应中的T细胞替代因子
Eur J Immunol. 1985 Jan;15(1):52-9. doi: 10.1002/eji.1830150111.
5
cAMP is an essential signal in the induction of antibody production by B cells but inhibits helper function of T cells.环磷酸腺苷（cAMP）是B细胞诱导抗体产生过程中的一种重要信号，但会抑制T细胞的辅助功能。
J Immunol. 1985 Sep;135(3):2084-9.
6
Lymphokine-induced suppressor B cells.淋巴因子诱导的抑制性B细胞
Immunology. 1982 Jul;46(3):545-53.
7
TRF requirements for in vitro PFC responses to SRBC and R36a. I. TRF is distinct from IL 2 but indistinguishable from polyclonal BCSF.对绵羊红细胞（SRBC）和R36a的体外空斑形成细胞（PFC）反应的转移因子（TRF）需求。I. TRF与白细胞介素2不同，但与多克隆B细胞刺激因子无法区分。
J Immunol. 1984 Mar;132(3):1305-10.
8
Analysis of T cell-replacing factor-like activity: potent induction of T helper activity for human B cells by residual concanavalin A and interleukin 2.T细胞替代因子样活性分析：残留伴刀豆球蛋白A和白细胞介素2对人B细胞T辅助活性的强力诱导
Eur J Immunol. 1987 Aug;17(8):1145-50. doi: 10.1002/eji.1830170811.
9
Human T cell-replacing factor(s): a comparison of recombinant and purified human B cell growth and differentiation factors.
Eur J Immunol. 1989 Nov;19(11):2045-9. doi: 10.1002/eji.1830191112.
10
Antigen-nonspecific helper factors in the antibody response.抗体应答中的抗原非特异性辅助因子。
Fed Proc. 1982 Feb;41(2):263-8.

引用本文的文献

1
Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.迈向对适应性免疫的分子理解：年表，第三部分。
Front Immunol. 2014 Feb 4;5:29. doi: 10.3389/fimmu.2014.00029. eCollection 2014.
2
The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.IL-2/CD25通路决定了人类和非肥胖糖尿病（NOD）小鼠对1型糖尿病的易感性。
J Clin Immunol. 2008 Nov;28(6):685-96. doi: 10.1007/s10875-008-9237-9. Epub 2008 Sep 9.
3
Gammadelta+ T cells preferentially respond to live rather than killed malaria parasites.γδ+ T细胞对活的疟原虫而非死的疟原虫有优先反应。
Infect Immun. 1998 May;66(5):2393-8. doi: 10.1128/IAI.66.5.2393-2398.1998.
4
Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi.对马来布鲁线虫天然和重组gp15/400（多蛋白变应原）的基因控制免疫反应的精细特异性
Infect Immun. 1995 Aug;63(8):2892-8. doi: 10.1128/iai.63.8.2892-2898.1995.
5
Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.初始CD4 T细胞进入外周淋巴结需要L-选择素。
J Exp Med. 1994 Dec 1;180(6):2401-6. doi: 10.1084/jem.180.6.2401.
6
T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.T细胞衍生的B细胞分化因子。对小鼠B细胞同种型转换的影响。
J Exp Med. 1982 Mar 1;155(3):734-48. doi: 10.1084/jem.155.3.734.
7
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.从一个克隆的T细胞系产生B细胞生长促进活性物质（DL）BCGF及其对BCL1 B细胞肿瘤的检测
J Exp Med. 1982 Dec 1;156(6):1821-34. doi: 10.1084/jem.156.6.1821.
8
Antigen-specific human T-cell hybridomas with helper activity.具有辅助活性的抗原特异性人T细胞杂交瘤。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6646-50. doi: 10.1073/pnas.79.21.6646.
9
A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion.一种单克隆T细胞替代活性可直接作用于B细胞以增强克隆扩增。
J Exp Med. 1982 Jul 1;156(1):306-11. doi: 10.1084/jem.156.1.306.
10
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.

本文引用的文献

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Induction and suppression of polyclonal antibody responses by anti-Ig reagents and antigen-nonspecific helper factors: a comparison of the effects of anti-Fab, anti-IgM, and anti IgD on murine B cells.抗Ig试剂和抗原非特异性辅助因子对多克隆抗体反应的诱导与抑制：抗Fab、抗IgM和抗IgD对小鼠B细胞作用的比较
Immunol Rev. 1980;52:115-39. doi: 10.1111/j.1600-065x.1980.tb00333.x.
2
Biochemical and biologic characterization of lymphocyte regulatory molecules. III. The isolation and phenotypic characterization of Interleukin-2 producing T cell lymphomas.淋巴细胞调节分子的生化与生物学特性。III. 产生白细胞介素-2的T细胞淋巴瘤的分离及表型特征分析
J Immunol. 1980 Dec;125(6):2570-8.
3
Thymoma production of T cell growth factor (Interleukin 2).胸腺瘤产生T细胞生长因子（白细胞介素2）。
J Immunol. 1980 Dec;125(6):2555-8.
4
Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.伴刀豆球蛋白A诱导的、产生白细胞介素-2的T细胞杂交瘤
J Exp Med. 1980 Oct 1;152(4):893-904. doi: 10.1084/jem.152.4.893.
5
A con A-stimulated T-cell hybridoma releases factors affecting haematopoietic colony-forming cells and B-cell antibody responses.刀豆蛋白A刺激的T细胞杂交瘤释放影响造血集落形成细胞和B细胞抗体反应的因子。
Nature. 1980 Jan 10;283(5743):197-9. doi: 10.1038/283197a0.
6
Production of Con A-induced helper T cell replacing factor requires a T cell and an Ia-positive non-T cells.刀豆蛋白A诱导的辅助性T细胞替代因子的产生需要一个T细胞和一个Ia阳性非T细胞。
J Immunol. 1980 Jan;124(1):437-44.
7
Fine specificity mapping of two allospecific T cell lines: recognition of private specificities in the H-2 IA subregion.
Eur J Immunol. 1981 Jan;11(1):62-4. doi: 10.1002/eji.1830110113.
8
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.增殖性和辅助性T细胞活性的组织相容性需求分析。通过阴性选择去除同种反应性细胞的T细胞群体。
J Exp Med. 1980 Nov 1;152(5):1311-28. doi: 10.1084/jem.152.5.1311.
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Mitogens as probes for immunocyte activation and cellular cooperation.有丝分裂原作为免疫细胞激活和细胞协作的探针。
Transplant Rev. 1972;11:131-77. doi: 10.1111/j.1600-065x.1972.tb00048.x.
10
Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.体外T和B淋巴细胞的激活。II. 一种在触发特异性B淋巴细胞中起作用的同种异体效应因子（AEF）的生物学和生化特性。
J Exp Med. 1974 Jul 1;140(1):19-37. doi: 10.1084/jem.140.1.19.

经刺激的T细胞系的培养上清液具有辅助活性，该活性在B细胞对抗原的应答中与白细胞介素2协同发挥作用。

Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen.

作者信息

Swain S L, Dennert G, Warner J F, Dutton R W

出版信息

Proc Natl Acad Sci U S A. 1981 Apr;78(4):2517-21. doi: 10.1073/pnas.78.4.2517.

DOI:10.1073/pnas.78.4.2517
PMID:6787609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC319378/
Abstract

Culture supernatants of an antigen-stimulated long-term alloreactive T cell line, C.C3.11.75, contain a T-cell-replacing factor (TRF) activity for the B-cell response to antigen. These same supernatants show little activity in the T-cell growth assay or the costimulator assay. TRF activity was assayed by using spleen cells that were rigorously depleted of both T cells and macrophages. In this assay preparations containing interleukin 2 and supernatants from stimulated C.C3.11.75 cells are relatively inactive if added alone but show marked synergy when added together. We conclude that the C.C3.11.75 TRF activity is not due to interleukin 1 or to interleukin 2 but to a third factor provisionally designated as (DL)TRF. This activity may be equivalent to the (late-acting) TRF described by Schimpl and Wecker. Evidence is presented suggesting that the helper activity (DL)TRF is a product of the T-cell line.

摘要

抗原刺激的长期同种异体反应性T细胞系C.C3.11.75的培养上清液含有一种T细胞替代因子（TRF）活性，可促进B细胞对抗原的反应。这些相同的上清液在T细胞生长试验或共刺激试验中活性很低。通过使用严格去除T细胞和巨噬细胞的脾细胞来检测TRF活性。在该试验中，如果单独添加含有白细胞介素2的制剂和来自受刺激的C.C3.11.75细胞的上清液，它们相对无活性，但一起添加时则显示出明显的协同作用。我们得出结论，C.C3.11.75的TRF活性不是由于白细胞介素1或白细胞介素2，而是由于一种暂时命名为（DL）TRF的第三种因子。这种活性可能等同于Schimpl和Wecker描述的（晚期作用）TRF。有证据表明辅助活性（DL）TRF是T细胞系的产物。