Occelli G, Saban Y, Barbarin A, Pourcher N, Michel A M, Maestracci P
Ann Fr Anesth Reanim. 1983;2(4):300-3. doi: 10.1016/s0750-7658(83)80027-6.
Four patients were studied following an anaphylactoid accident occurring during general anaesthesia. Histamine release was assessed on clinical signs, basophil degranulation and, in one case, an early serum histamine peak. Past medical history revealed previous allergies in all cases. An immunological study showed that IgE, CH50, C3 and C4 serum levels were within the normal range. Skin reactivity to histamine was normal in all but one case. In every case, one of the drugs used during the anaesthetic gave a positive skin test and was considered as the causative agent. There were discrepancies between the in vitro and in vivo tests of basophil degranulation, a second drug being positive in one case, and several drugs inducing abnormal degranulation reactions in the other cases. The drugs considered as involved in these accidents are noteworthy: suxamethonium (two cases), fluid gelatin (Plasmion) and droperidol. The results are discussed by the authors.
对4例在全身麻醉期间发生类过敏反应的患者进行了研究。通过临床体征、嗜碱性粒细胞脱颗粒情况以及在1例患者中出现的早期血清组胺峰值来评估组胺释放情况。既往病史显示所有病例均有既往过敏史。免疫学研究表明，IgE、CH50、C3和C4血清水平均在正常范围内。除1例患者外，其他所有患者对组胺的皮肤反应性均正常。在每例病例中，麻醉期间使用的一种药物皮肤试验呈阳性，并被视为致病因素。嗜碱性粒细胞脱颗粒的体外和体内试验结果存在差异，1例中另一种药物呈阳性，其他病例中有几种药物诱导异常脱颗粒反应。被认为与这些不良反应有关的药物值得注意：琥珀胆碱（2例）、液体明胶（血浆代用品）和氟哌利多。作者对结果进行了讨论。
