Leynadier F, Luce H, Dry J
Sem Hop. 1984 Apr 5;60(15):1029-33.
Analysis of fifty-five anaphylactoid accidents during general anesthesia (GA) in fifty patients shows significant female predominance (70%), relatively frequent allergic predisposition (34% as compared to 14.3% in a normal population) and fairly frequent responsibility of suxamethonium and succinylcholine. One or more, even recent, previous GAs do not seem to enhance the risk. 50% of intradermal skin tests to different anesthetics were negative, 40% were positive and consistent with clinical history, and 10% were positive but inconsistent clinically. Biological tests (basophil degranulation, lymphoblast rosettes, in vitro consumption of complement) were negative. Physiopathological mechanisms remain uncertain, whether they involve IgE allergy or complement activation. The frequency and severity of these unpredictable accidents must stimulate clinical and biological research in this field.
对50例患者在全身麻醉（GA）期间发生的55起类过敏反应事故的分析表明，女性占显著优势（70%），过敏倾向相对常见（34%，而正常人群中为14.3%），琥珀酰胆碱和司可林的责任相当常见。一次或多次，甚至近期的既往全身麻醉似乎不会增加风险。对不同麻醉剂进行的皮内皮肤试验，50%为阴性，40%为阳性且与临床病史相符，10%为阳性但临床不符。生物学试验（嗜碱性粒细胞脱颗粒、成淋巴细胞玫瑰花结、体外补体消耗）均为阴性。生理病理机制仍不确定，无论其是否涉及IgE过敏或补体激活。这些不可预测事故的发生频率和严重程度必须推动该领域的临床和生物学研究。
