Huber J F, Bischof P, Extermann P, Beguin F, Herrmann W L
Br J Obstet Gynaecol. 1983 Dec;90(12):1183-5. doi: 10.1111/j.1471-0528.1983.tb06469.x.
Vaginal fluid levels of prolactin (Prl), alpha-fetoprotein (AFP) and human placental lactogen (hPL) were assayed to investigate their usefulness in the diagnosis of ruptured membranes. Fifty-two patients at term were divided into those with intact membranes, and those with ruptured membranes. In patients with intact membranes the concentration of all three substances was low with few exceptions. The mean vaginal concentrations of the three proteins were significantly higher in patients with ruptured membranes, but low values were also found in this group. It is concluded, that because of the overlap between the values, Prl, AFP and hPL measurements in vaginal fluid do not represent a useful advance in the assessment of rupture of the membranes.
检测阴道液中催乳素（Prl）、甲胎蛋白（AFP）和人胎盘催乳素（hPL）的水平，以研究它们在胎膜破裂诊断中的作用。52名足月孕妇被分为胎膜完整组和胎膜破裂组。胎膜完整的患者中，除少数例外，这三种物质的浓度均较低。胎膜破裂患者这三种蛋白质的平均阴道浓度显著较高，但该组中也有低值出现。得出的结论是，由于这些值存在重叠，阴道液中Prl、AFP和hPL的测量在评估胎膜破裂方面并没有带来有效的进展。
