Koninckx P R, Trappeniers H, Van Assche F A
Br J Obstet Gynaecol. 1981 Jun;88(6):607-10. doi: 10.1111/j.1471-0528.1981.tb01216.x.
Prolactin concentrations were assayed in vaginal fluid, urine and plasma in 20 women between 38 and 41 weeks gestation. Plasma concentrations of 12.3 (7.3-20.8) mU/ml (n = 40) were found whereas urine concentrations were low or undetectable. Vaginal fluid concentrations were generally lower than 0.25 mU/ml but occasionally elevated up to 3 mU/ml in women with unruptured membranes. Half an hour after artificial rupture of the membranes, vaginal fluid prolactin concentrations were always higher than paired maternal plasma concentrations (p less than 0.001). In women suspected of premature rupture of the membranes, prolactin concentrations in vaginal fluid were always higher than the plasma concentrations except in those in whom the clinical outcome showed that the membranes had not ruptured. A rapid prolactin radioimmunoassay is therefore recommended as a new clinical tool for the diagnosis or exclusion of prematurely ruptured membranes.
对20名妊娠38至41周的女性的阴道液、尿液和血浆中的催乳素浓度进行了测定。血浆浓度为12.3（7.3 - 20.8）mU/ml（n = 40），而尿液浓度较低或无法检测到。阴道液浓度一般低于0.25 mU/ml，但胎膜未破裂的女性偶尔会升高至3 mU/ml。人工破膜半小时后，阴道液催乳素浓度总是高于配对的母体血浆浓度（p < 0.001）。在怀疑胎膜早破的女性中，除了临床结果显示胎膜未破裂的那些女性外，阴道液中的催乳素浓度总是高于血浆浓度。因此，推荐一种快速催乳素放射免疫测定法作为诊断或排除胎膜早破的一种新的临床工具。
