Bowersox S S, Sterman M B
Electroencephalogr Clin Neurophysiol. 1983 Dec;56(6):623-7. doi: 10.1016/0013-4694(83)90029-9.
The present study describes changes in circadian state pattern organization associated with somatosensory deafferentation in the adult cat. Nine animals, implanted for chronic monitoring of standard sleep state variables, were divided into 3 groups for study. Six cats received dorsal column transections at either a high (C1-C3, N = 3) or low (C5-T1, N = 3) cervical level. The remaining three served as intact controls. State evaluations of continuous 24 h polygraphic recordings disclosed a significant facilitation of alert waking and a suppression of slow wave sleep in animals with high cervical lesions; REM sleep was not affected. State pattern percentages for animals with low cervical lesions were comparable to those of intact controls; however, lesioned animals of both experimental groups showed changes in the frequency of occurrence and duration of individual sleep/wake episodes. These findings were interpreted in terms of the enhancement of intrinsic rhythmic discharge patterns over ventrobasal thalamocortical pathways.
本研究描述了成年猫体感传入神经切断后昼夜节律状态模式组织的变化。9只植入电极用于长期监测标准睡眠状态变量的动物被分为3组进行研究。6只猫在高位（C1 - C3，n = 3）或低位（C5 - T1，n = 3）颈髓水平接受了背柱横切术。其余3只作为完整对照。对连续24小时多导睡眠图记录的状态评估显示，高位颈髓损伤的动物警觉觉醒显著增加，慢波睡眠受到抑制；快速眼动睡眠未受影响。低位颈髓损伤动物的状态模式百分比与完整对照相当；然而，两个实验组的损伤动物在个体睡眠/觉醒发作的发生频率和持续时间上均出现了变化。这些发现被解释为腹侧基底丘脑皮质通路内在节律性放电模式的增强。
