Chiu I M, Callahan R, Tronick S R, Schlom J, Aaronson S A
Science. 1984 Jan 27;223(4634):364-70. doi: 10.1126/science.6197754.
The genetic relationships among molecularly cloned prototype viruses representing all of the major oncovirus genera were investigated by molecular hybridization and nucleotide sequence analysis. One of the major progenitors of the pol genes of such viruses gives rise to mammalian type C viruses and another gives rise to type A, B, D, and avian type C oncoviruses. Evidence of unusual patterns of homology among the env genes of mammalian type C and D oncoviruses illustrates that genetic interactions between their progenitors contributed to the evolution of oncoviruses.
通过分子杂交和核苷酸序列分析，研究了代表所有主要致癌病毒属的分子克隆原型病毒之间的遗传关系。这类病毒pol基因的主要祖源之一产生了哺乳动物C型病毒，另一个祖源则产生了A、B、D型以及禽C型致癌病毒。哺乳动物C型和D型致癌病毒env基因之间存在异常同源模式的证据表明，它们的祖源之间的遗传相互作用促进了致癌病毒的进化。
