念珠菌属不同种的酸性蛋白酶分泌情况。

Secretion of acid proteinases by different species of the genus Candida.

作者信息

Rüchel R, Uhlemann K, Böning B

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1983 Nov;255(4):537-48.

PMID:6197827

Abstract

Strains of several Candida species that are isolated from humans aside of C. albicans have been screened for secretion of acid proteinases. A third of the strains of C. tropicalis was strongly proteolytic, other strains of this species were moderately or virtually nonproteolytic; the variety of activities resembled pattern found among strains of C. albicans (32). Strains of C. parapsilosis produced 24% of the proteolytic activity of strongly proteolytic strains of C. tropicalis. The proteolytic activity of C. pseudotropicalis, C. krusei, and C. glabrata accounted for 7.5, 2.0, and 0.8% respectively. Four strains of C. guilliermondii developed strain-specific proteolysis after prolonged cultivation only. Five proteinases from strains of C. tropicalis cross reacted immunologically as did five proteinases from C. albicans. Interspecific cross reaction, though, was not observed when certain sera from rabbits were employed.

摘要

除白色念珠菌外，已对从人类分离出的几种念珠菌属菌株进行了酸性蛋白酶分泌筛选。热带念珠菌三分之一的菌株具有强蛋白水解活性，该菌种的其他菌株则为中度或几乎无蛋白水解活性；其活性变化与白色念珠菌菌株中发现的模式相似（32）。近平滑念珠菌菌株产生的蛋白水解活性为热带念珠菌强蛋白水解菌株的24%。伪热带念珠菌、克柔念珠菌和光滑念珠菌的蛋白水解活性分别占7.5%、2.0%和0.8%。仅在长期培养后，四株季也蒙念珠菌才产生菌株特异性蛋白水解作用。热带念珠菌菌株的五种蛋白酶与白色念珠菌的五种蛋白酶发生免疫交叉反应。不过，当使用兔的某些血清时，未观察到种间交叉反应。