Rüchel R
Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Jul;257(2):266-74.
Acid proteinases are secreted by the majority of strains of Candida albicans, C. tropicalis and C. parapsilosis, reflecting the sequence of virulence of Candida spp. for man. As revealed by exposure to various substrates and inhibitors, Candida proteinases are strain-specific, although close relationships exist between enzymes from strains of the same species. Possible targets of hydrolytic attack by Candida proteinases in the host are immunoglobulins, the proteinase scavenger alpha-2-macroglobulin, zymogens of regulatory serine proteinases such as coagulation factor X, and angiotensinogen. The involvement of Candida proteinase in the pathogenesis of acronecrosis is discussed.
大多数白色念珠菌、热带念珠菌和近平滑念珠菌菌株都会分泌酸性蛋白酶，这反映了念珠菌属对人类的致病力顺序。通过接触各种底物和抑制剂发现，念珠菌蛋白酶具有菌株特异性，尽管同一物种菌株的酶之间存在密切关系。念珠菌蛋白酶在宿主体内可能的水解攻击靶点包括免疫球蛋白、蛋白酶清除剂α-2-巨球蛋白、调节性丝氨酸蛋白酶的酶原（如凝血因子X）和血管紧张素原。本文讨论了念珠菌蛋白酶在肢端坏死发病机制中的作用。
