Goitein K J, Shohami E
J Neurol. 1983;230(4):259-66. doi: 10.1007/BF00313702.
Experiments were carried out in cats to examine the relationship between prolonged convulsions and intracranial pressure. The convulsions were induced by pentylenetetrazole or bicuculline. Blood pressure, intracranial pressure and electroencephalogram were continuously monitored. Generalized tonic-clonic convulsions appeared with typical changes in the electroencephalogram 7-35 s after administration of the epileptogenic drugs. These convulsions persisted for 1-2 h. Concomitant with the clinical convulsions, intracranial pressure increased three- to fivefold, reaching maximal pressures of 20-94 mm Hg after 20-420s. The intracranial pressure remained high for between 47 s and 10 min, then began to fall gradually, reaching preictal levels after 2-30 min despite the continuation of convulsions. The variations in intracranial pressure were found to be independent of changes in blood pressure. The intracranial pressure, after dropping to preictal values, remained unchanged for up to 6 h after the induction of convulsions.
在猫身上进行了实验，以研究长时间惊厥与颅内压之间的关系。惊厥由戊四氮或荷包牡丹碱诱发。连续监测血压、颅内压和脑电图。在给予致痫药物7 - 35秒后，出现全身性强直阵挛性惊厥，并伴有脑电图的典型变化。这些惊厥持续1 - 2小时。伴随着临床惊厥，颅内压升高三到五倍，在20 - 420秒后达到20 - 94毫米汞柱的最大压力。颅内压在47秒至10分钟内保持高位，然后开始逐渐下降，尽管惊厥仍在持续，但在2 - 30分钟后达到发作前水平。发现颅内压的变化与血压变化无关。惊厥诱发后，颅内压降至发作前值后，在长达6小时内保持不变。
