Thiers B H, Maize J C, Spicer S S, Cantor A B
J Invest Dermatol. 1984 Mar;82(3):223-6. doi: 10.1111/1523-1747.ep12260055.
ATPase histochemistry was used to examine Langerhans cell (LC) populations in the skin of young persons with no evidence of solar damage and older adults with chronic actinically damaged skin. The number of LC was significantly decreased in the older age group. Significantly fewer LC were observed in exposed vs covered skin in the older individuals; no such disparity was noted in the younger subjects. Morphologic alterations in ATPase-positive cells were noted in some specimens, most of which were taken from the exposed skin of elderly persons. The results suggest an independent, although possibly additive, quantitative and qualitative influence of aging and chronic sun exposure on the LC population. Decreased numbers of LC in the sun-damaged skin of elderly individuals may play a critical permissive role in the development of cutaneous carcinoma.
采用ATP酶组织化学方法检测无日光损伤迹象的年轻人以及患有慢性光化性皮肤损伤的老年人皮肤中的朗格汉斯细胞细胞细胞（LC）群体。老年组中LC数量显著减少。在老年人中，暴露皮肤处观察到的LC明显少于遮盖皮肤处；而在年轻受试者中未发现这种差异。在一些标本中注意到ATP酶阳性细胞的形态学改变，其中大部分取自老年人的暴露皮肤。结果表明，衰老和慢性阳光照射对LC群体具有独立的（尽管可能是累加的）定量和定性影响。老年人日光损伤皮肤中LC数量减少可能在皮肤癌的发生中起关键的促成作用。
