四氯化碳对亚硝基胺诱发小鼠肝脏和肾脏肿瘤的影响。
Influence of carbon tetrachloride on induction of tumours of the liver and kidneys in mice by netrosamines.
作者信息
Pound A W
出版信息
Br J Cancer. 1978 Jan;37(1):67-75. doi: 10.1038/bjc.1978.10.
Abstract
Mice were given a single dose of nitrosolimethylamine, nitrosoliethylamine or nitrosomethylethylamine and the yield of tumours and related lesions in the livers determined 12 months later. A hepatonecrotic dose of CCl4 24 or 48 h before the nitrosamines, increased the yields of hepatocellular tumours and proliferative foci in the livers, whereas when given 60 h before the nitrosamines there was no significant effect.
摘要
给小鼠单次注射亚硝基二甲基胺、亚硝基二乙胺或亚硝基甲乙胺，并于12个月后测定肝脏中的肿瘤及相关病变的发生率。在给予亚硝胺前24或48小时给予肝坏死剂量的四氯化碳，可增加肝脏中肝细胞肿瘤和增生灶的发生率，而在给予亚硝胺前60小时给予四氯化碳则无显著影响。
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