重复肝脏再生对二乙基亚硝胺诱导小鼠肝癌发生的影响。
Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice.
作者信息
Poound A W, McGuire L J
出版信息
Br J Cancer. 1978 Apr;37(4):595-602. doi: 10.1038/bjc.1978.89.
Abstract
In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers. A single hepatonecrotic dose of CCl4 24 h before a single dose of DEN also increased the number of tumours produced. The effect of the repeated administration of CCl4 after the dose of DEN occurred in addition to, and was therefore independent of, the enhancing effect of a single dose of CCl4 before DEN. These results may be interpreted as implying (1) that the liver in the regenerative phase after a hepatonecrotic dose of CCl4 is more susceptible to an initiating action of DEN, i.e. produces more potential foci of tumour growth than in the normal liver and (2) that the repeated doses of CCl4 leading to repeated phases of regeneration, after the dose of DEN, provide a promoting stimulus.
摘要
给小鼠单次注射二乙基亚硝胺后，给予肝坏死剂量的四氯化碳，在注射二乙基亚硝胺5周后，每隔4周重复给药6次，可增加肝脏中的肿瘤发生率。在单次注射二乙基亚硝胺前24小时给予单次肝坏死剂量的四氯化碳，也会增加所产生的肿瘤数量。在注射二乙基亚硝胺后重复给予四氯化碳的效果，是在单次注射二乙基亚硝胺前给予四氯化碳的增强作用之外发生的，因此与之无关。这些结果可以解释为意味着：（1）在给予肝坏死剂量的四氯化碳后的再生阶段，肝脏对二乙基亚硝胺的启动作用更敏感，即比正常肝脏产生更多潜在的肿瘤生长灶；（2）在注射二乙基亚硝胺后，重复给予四氯化碳导致再生的重复阶段，提供了一种促进刺激。
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本文引用的文献
1
Tissue regeneration and tumour development.组织再生与肿瘤发展。
Br J Cancer. 1959 Dec;13(4):669-74. doi: 10.1038/bjc.1959.74.
2
COCARCINOGENESIS.协同致癌作用
Br Med Bull. 1964 May;20:139-44. doi: 10.1093/oxfordjournals.bmb.a070307.
3
A possible two-stage mechanism in rhabdomyosarcoma induction in rats.大鼠横纹肌肉瘤诱导过程中可能的两阶段机制。
Br J Cancer. 1962 Dec;16(4):653-64. doi: 10.1038/bjc.1962.76.
4
Tumor induction as a measure of genetic damage and repair in somatic cells of mice.肿瘤诱导作为小鼠体细胞遗传损伤与修复的一种衡量指标。
Radiat Res. 1968 May;34(2):315-9.
5
Alteration of drug metabolism during rat liver regeneration.大鼠肝脏再生过程中药物代谢的改变。
Arch Int Pharmacodyn Ther. 1971 Feb;189(2):373-5.
6
Radiation carcinogenesis: the sequence of events.
Science. 1965 Dec 31;150(3705):1782-6. doi: 10.1126/science.150.3705.1782.
7
The function and mechanism of promoters of carcinogenesis.致癌作用启动子的功能与机制。
CRC Crit Rev Toxicol. 1974 Jan;2(4):419-43. doi: 10.3109/10408447309025704.
8
A comparison of the effects of partial surgical and partial chemical (CCl 4) hepatectomy on microsomal cytochrome b 5 and P 450 and oxidative N-demethylation.
Agents Actions. 1969 Jul;1(1):27-34. doi: 10.1007/BF01990017.
9
[The effect of partial hepatectomies on the hepatoma rate after administration of diethyl-nitrosamine].
Z Naturforsch B. 1970 Nov;25(11):1277-81.
10
Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride.在预先给予四氯化碳后，二甲基亚硝胺的致癌作用增强。
Br J Cancer. 1973 Jun;27(6):451-9. doi: 10.1038/bjc.1973.57.
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