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1
Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice.未治疗和经聚阳离子处理的AKR小鼠的寿命、白血病发病率和淀粉样蛋白发病率。
Br J Cancer. 1978 Jan;37(1):76-80. doi: 10.1038/bjc.1978.11.
2
Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.二乙氨基乙基葡聚糖、聚凝胺、葡聚糖和硫酸葡聚糖对AKR小鼠自发性白血病发生及BALB - c小鼠病毒诱导白血病的影响。
Br J Cancer. 1974 Jul;30(1):68-72. doi: 10.1038/bjc.1974.114.
3
Mutually exclusive occurrence of amyloidosis and thymic leukaemia in casein treated AKR mice.酪蛋白处理的AKR小鼠中淀粉样变性和胸腺白血病的互斥发生。
Br J Cancer. 1974 Jan;29(1):76-9. doi: 10.1038/bjc.1974.10.
4
Effect of static magnetic fields on survival of leukaemia-prone AKR mice.静磁场对白血病易感AKR小鼠存活率的影响。
Radiat Environ Biophys. 1986;25(1):75-80. doi: 10.1007/BF01209687.
5
Effect of polycations on the early stages of reovirus infection.
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Adoptive immunotherapy and combined chemo-immunotherapy in transplantable leukaemia of AKR mice (TAL); occurrence of natural killers.
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Correlation between mean litter size and mean life span among 12 inbred strains of mice.
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Effect of different components of the thymic stroma on the onset of AKR leukaemia.胸腺基质不同成分对AKR白血病发病的影响。
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Alterations in CFU-GM growth in preleukaemic and leukaemic AKR/J mice.白血病前期和白血病AKR/J小鼠中CFU-GM生长的改变。
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引用本文的文献

1
Variations in erythropoiesis throughout a lifetime. Studies in a high-leukaemic mouse strain, the AKR/O strain, and a non-leukaemic strain, the WLO strain.一生中红细胞生成的变化。对高白血病小鼠品系AKR/O品系和非白血病品系WLO品系的研究。
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本文引用的文献

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A membrane effect of basic polymers dependent on molecular size.碱性聚合物的膜效应取决于分子大小。
Nature. 1967 Aug 26;215(5104):934-6. doi: 10.1038/215934a0.
2
Growth and senescence of antibody-forming cells.抗体形成细胞的生长与衰老
J Cell Physiol. 1966 Jun;67(3):Suppl 1:185+. doi: 10.1002/jcp.1040670415.
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Standardized nomenclature for inbred strains of mice: fifth listing.小鼠近交系标准化命名法：第五版名录
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Abrogated thymoma development and increased amyloid development in estrogenized mice grafted spleen and bone marrow cells.在移植了脾脏和骨髓细胞的雌激素化小鼠中，胸腺瘤发育被抑制，淀粉样物质生成增加。
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Spontaneous reticular neoplasms in (CBA X DBA/2)F1 mice, with special emphasis on the occurrence of plasma cell neoplasms.
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6
Mutually exclusive occurrence of amyloidosis and thymic leukaemia in casein treated AKR mice.酪蛋白处理的AKR小鼠中淀粉样变性和胸腺白血病的互斥发生。
Br J Cancer. 1974 Jan;29(1):76-9. doi: 10.1038/bjc.1974.10.
7
Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.二乙氨基乙基葡聚糖、聚凝胺、葡聚糖和硫酸葡聚糖对AKR小鼠自发性白血病发生及BALB - c小鼠病毒诱导白血病的影响。
Br J Cancer. 1974 Jul;30(1):68-72. doi: 10.1038/bjc.1974.114.
8
DEAE-dextran and polybrene cation enhancement and dextran sulfate anion inhibition of immune cytolysis.二乙氨基乙基葡聚糖和多聚凝胺的阳离子增强作用以及硫酸葡聚糖的阴离子抑制免疫细胞溶解作用。
J Immunol. 1972 Dec;109(6):1296-9.
9
Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control.实验性淀粉样变性：诱导剂是一种多克隆B细胞激活剂，对其易感性受基因控制。
J Exp Med. 1975 Dec 1;142(6):1564-9. doi: 10.1084/jem.142.6.1564.
10
Transformation of thymocytes by thymus epithelium derived from AKR mice.
Nature. 1976 Oct 7;263(5577):512-4. doi: 10.1038/263512a0.

未治疗和经聚阳离子处理的AKR小鼠的寿命、白血病发病率和淀粉样蛋白发病率。

Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice.

作者信息

Ebbesen P

出版信息

Br J Cancer. 1978 Jan;37(1):76-80. doi: 10.1038/bjc.1978.11.

DOI:10.1038/bjc.1978.11
PMID:619959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009506/
Abstract

AKR mice, which have a short mean survival time and usually die with leukaemia, were studied from one month of age for correlation between these two parameters. For untreated animals we found the same mean survival time whether or not leukaemia occurred. By treating sucklings with the polycations diethylaminoethyl-dextran or hexadimethrine bromide the leukaemia incidence was significantly reduced. However, the mean survival time was unchanged, and remained the same in leukaemic and non-leukaemic animals. It is therefore suggested that the early death of AKR mice results from an ageing process and does not require leukaemia for implementation. Our prophylactic polycation treatment was furthermore found to induce spleen amyloid in some but not all of the mice that remained non-leukaemic.

摘要

对平均存活时间较短且通常死于白血病的AKR小鼠从1月龄起进行研究，以探讨这两个参数之间的相关性。对于未经治疗的动物，无论是否发生白血病，我们发现其平均存活时间相同。通过用聚阳离子二乙氨基乙基葡聚糖或溴化六甲双铵处理乳鼠，白血病发病率显著降低。然而，平均存活时间没有变化，白血病小鼠和非白血病小鼠的平均存活时间保持相同。因此表明，AKR小鼠的早期死亡是由衰老过程导致的，白血病的发生并非其早期死亡的必要条件。此外，我们还发现预防性聚阳离子治疗在一些但并非所有未患白血病的小鼠中诱发了脾脏淀粉样变。