Wardman A G, Bowen M, Struthers L P, Cooke N J
Med Pediatr Oncol. 1984;12(1):68-72. doi: 10.1002/mpo.2950120116.
We submitted 83 consecutive patients with pleural effusion to routine clinical investigation; 57 were diagnosed as malignant, 18 as benign, and 8 were not diagnosed. Pleural fluid and serum were analysed for carcinoembryonic antigen (CEA), acid glycoprotein (AGP), antichymotrypsin (ACT), C-reactive protein (CRP), alpha 2-pregnancy associated glycoprotein (alpha 2-PAG) and ferritin. Multivariate discriminant analysis was performed on the results of the protein measurements. CEA and ACT values in serum and fluid were found to give a good discriminating function between the benign and malignant groups. The use of such an analysis, in a clinical context, is discussed.
我们对83例连续的胸腔积液患者进行了常规临床检查；57例被诊断为恶性，18例为良性，8例未明确诊断。对胸腔积液和血清进行了癌胚抗原（CEA）、酸性糖蛋白（AGP）、抗胰凝乳蛋白酶（ACT）、C反应蛋白（CRP）、α2妊娠相关糖蛋白（α2-PAG）和铁蛋白的分析。对蛋白质测量结果进行了多变量判别分析。发现血清和积液中的CEA和ACT值在良性和恶性组之间具有良好的判别功能。讨论了这种分析在临床环境中的应用。
