胃癌的血浆蛋白谱与预后
Plasma protein profiles and prognosis in gastric cancer.
作者信息
Rashid S A, O'Quigley J, Axon A T, Cooper E H
出版信息
Br J Cancer. 1982 Mar;45(3):390-4. doi: 10.1038/bjc.1982.66.
Abstract
In 104 patients with gastric cancer the serum proteins carcinoembryonic antigen (CEA), C-reactive protein (CRP), alpha 1-acid glycoprotein (AGP) (orosomucoid) and alpha 1-antichymotrypsin (ACT) were measured pre-operatively. The estimated median survival of patients with both raised CEA and ACT was only 5 weeks in contrast to 64 weeks for those with both proteins normal. An intermediary group with one of these proteins raised and the other normal had an estimated median survival of 15 weeks. Similar results were obtained by considering a combination of CEA with either AGP or CRP. For these data the results were not explicable in terms of associations between survival time and patient's age, stage, operative procedure, histological classification or site of primary tumour.
摘要
对104例胃癌患者术前测定了血清蛋白癌胚抗原（CEA）、C反应蛋白（CRP）、α1-酸性糖蛋白（AGP）（类粘蛋白）和α1-抗糜蛋白酶（ACT）。CEA和ACT均升高的患者估计中位生存期仅为5周，而这两种蛋白均正常的患者为64周。其中一种蛋白升高而另一种正常的中间组估计中位生存期为15周。通过考虑CEA与AGP或CRP的组合也得到了类似结果。对于这些数据，根据生存时间与患者年龄、分期、手术方式、组织学分类或原发肿瘤部位之间的关联无法解释这些结果。
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