Fujimoto G I, Morrill G A
Biochim Biophys Acta. 1978 Jan 18;538(2):226-30. doi: 10.1016/0304-4165(78)90349-5.
The effects of colchicine on 17 beta-estradiol-induced water and electrolyte uptake in the uterus of the immature rat have been examined 6 h after treatment with this estrogen. Estradiol stimulates an increase in total uterine Na+, K+ and water while intracellular Na+ and K+ concentrations remain relatively unchanged. Assuming the sodium space is equivalent to the extracellular space, the extracellular fluid compartment increases about 84% in response to estradiol. Similarly, the intracellular compartment increases by about 62%. The uptake of water into the cellular compartment may be a direct response to a stimulation of K+ accumulation by uterine cells. Colchicine inhibits both estradiol-induced rise in intracellular potassium and both intra- and extracellular water.
在用雌激素处理未成熟大鼠子宫6小时后，研究了秋水仙碱对17β-雌二醇诱导的水和电解质摄取的影响。雌二醇刺激子宫总钠、钾和水含量增加，而细胞内钠和钾浓度相对保持不变。假设钠空间等同于细胞外空间，那么细胞外液腔室因雌二醇而增加约84%。同样，细胞内腔室增加约62%。水进入细胞内腔室可能是子宫细胞钾积累受刺激的直接反应。秋水仙碱抑制雌二醇诱导的细胞内钾升高以及细胞内和细胞外水的增加。
