金属致癌作用的最新进展

Recent advances in metal carcinogenesis.

作者信息

Sunderman F W

出版信息

Ann Clin Lab Sci. 1984 Mar-Apr;14(2):93-122.

PMID:6201124

Abstract

Recent advances in metal carcinogenesis are comprehensively reviewed, including (a) epidemiological and clinical aspects, (b) carcinogenesis bioassays, (c) bacterial mutagenesis, (d) mammalian cell mutagenesis, (e) chromosomal damage, (f) mammalian cell transformation, (g) microsomal metabolism, (h) DNA strandbreaks and crosslinks, (i) DNA polymerase infidelity, (j) RNA strand initiation, and (k) helical transition of B-DNA to Z-DNA. Based upon these observations, several hypotheses are proposed for the molecular pathogenesis of carcinogenesis by metal compounds. These hypotheses are amenable to experimental test by existing techniques of molecular biology.

摘要

本文全面综述了金属致癌作用的最新进展，包括：（a）流行病学和临床方面；（b）致癌生物测定；（c）细菌诱变；（d）哺乳动物细胞诱变；（e）染色体损伤；（f）哺乳动物细胞转化；（g）微粒体代谢；（h）DNA链断裂和交联；（i）DNA聚合酶错误掺入；（j）RNA链起始；以及（k）B-DNA向Z-DNA的螺旋转变。基于这些观察结果，针对金属化合物致癌作用的分子发病机制提出了几种假说。这些假说可用现有的分子生物学技术进行实验验证。