Huber B, Cantor H, Shen F W, Boyse E A
J Exp Med. 1976 Oct 1;144(4):1128-33. doi: 10.1084/jem.144.4.1128.
When B mice are supplied with Ly1 or Ly23 cells they acquire, over the next 6 mo, only the immune functions associated with each of these T-cell subclasses, respectively. The T-cell population of these "B-Ly1" and "B-Ly23" mice mice also remains restricted to the Ly1 and Ly23 subclass phenotypes. Thus the Ly1 and Ly23 populations are derived from two separate lines of differentiation and are not sequential stages of a single differentiative pathway.
当向B小鼠提供Ly1或Ly23细胞时,在接下来的6个月里,它们分别仅获得与这些T细胞亚类各自相关的免疫功能。这些“B-Ly1”和“B-Ly23”小鼠的T细胞群体也仍然局限于Ly1和Ly23亚类表型。因此,Ly1和Ly23群体源自两条独立的分化谱系,而不是单一分化途径的连续阶段。