细胞介导的免疫：迟发型超敏反应和细胞毒性反应由不同的T细胞亚类介导。
Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses.
作者信息
Huber B, Devinsky O, Gershon R K, Cantor H
出版信息
J Exp Med. 1976 Jun 1;143(6):1534-9. doi: 10.1084/jem.143.6.1534.
Abstract
Cell-mediated immunity includes both the generation of cytotoxic cells and initiation of delayed-type hypersensitivity (DTH). The resting T-cell population, before stimulation by antigen, already contains cells of the Lyl subclass that are programmed to initiate DTH (and helper function) but not cytotoxic responses, as well as Ly23 cells which can generate killer activity (and suppressive function) but not DTH. The central implication of these findings is that the broad division between humoral and cell-mediated immune responses does not precisely correspond to the division of labor among T-cell subclasses. The relative contribution of DTH-competent Lyl cells and cytotoxic Ly23 cells to the classical homograft response remains to be determined.
摘要
细胞介导的免疫包括细胞毒性细胞的产生和迟发型超敏反应（DTH）的启动。在受到抗原刺激之前，静止的T细胞群体中已经包含Lyl亚类的细胞，这些细胞被编程启动DTH（和辅助功能）但不产生细胞毒性反应，以及Ly23细胞，它们可以产生杀伤活性（和抑制功能）但不产生DTH。这些发现的核心含义是，体液免疫反应和细胞介导免疫反应之间的广泛划分并不精确对应于T细胞亚类之间的分工。具有DTH能力的Lyl细胞和细胞毒性Ly23细胞对经典同种异体移植反应的相对贡献仍有待确定。
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