对强组织相容性抗原产生反应的淋巴细胞的特异性阳性选择。
Specific positive selection of lymphocytes reactive to strong histocompatibility antigens.
作者信息
Howard J C, Wilson D B
出版信息
J Exp Med. 1974 Sep 1;140(3):660-72. doi: 10.1084/jem.140.3.660.
Abstract
Selected populations of thymus-derived (T) rat lymphocytes having specific immunological reactivity to chosen histocompatibility (H) alloantigens are found among the cellular products of the mixed lymphocyte interaction (MLI). Such specific selection seems to depend on (a) the antigen-induced proliferation of specific H antigen reactive cells (HARC), and (b) the disappearance of nonreactive cells from the cultures. When the surviving cells from this lymphocyte-antigen interaction are transferred into thymectomized, X-irradiated, marrow-reconstituted syngeneic recipients (B rats) which lack detectable T-lymphocyte functions, the lymphocyte populations subsequently recovered from the hosts possess the capacity to react in the MLI and in the graft-vs.-host (GVH) reaction, and the reactions have specificity for the original priming alloantigens. In addition, these findings identify the cell that reacts in the MLI with the GVH reactive cell.
摘要
在混合淋巴细胞相互作用（MLI）的细胞产物中，发现了对选定的组织相容性（H）同种异体抗原有特异性免疫反应性的胸腺来源（T）大鼠淋巴细胞的特定群体。这种特异性选择似乎取决于：（a）抗原诱导的特异性H抗原反应性细胞（HARC）的增殖，以及（b）培养物中非反应性细胞的消失。当这种淋巴细胞 - 抗原相互作用中存活的细胞被转移到缺乏可检测到的T淋巴细胞功能的胸腺切除、X射线照射、骨髓重建的同基因受体（B大鼠）中时，随后从宿主中恢复的淋巴细胞群体具有在MLI和移植物抗宿主（GVH）反应中发生反应的能力，并且这些反应对原始致敏同种异体抗原有特异性。此外，这些发现确定了在MLI中与GVH反应性细胞发生反应的细胞。
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