舒洛芬与萘普生治疗骨关节炎疼痛的双盲研究。
Double-blind study of suprofen vs naproxen in the treatment of osteoarthritic pain.
作者信息
Fellmann N, Stocker H, Reuteler H
出版信息
Eur J Rheumatol Inflamm. 1983;6(2):216-21.
In a 2-week double-blind study involving 79 patients with mainly osteoarthritis of the hip and knee, Suprofen and Naproxen were compared for efficacy and tolerability in the treatment of the symptoms of the disease. The drugs were administered on a b.i.d. schedule: 800 mg of Suprofen or 750 mg of Naproxen. Nocturnal pain, pain at rest, pain on motion and tenderness were evaluated at baseline and at days 7 and 14. Results showed that patients in both groups were significantly improved in all parameters. Between the groups no statistically significant differences were found. Thus, Suprofen was as effective in pain relief as Naproxen. One patient in the Suprofen group and two patients in the Naproxen group experienced mild gastrointestinal symptoms. Overall tolerability was very good.
在一项为期2周的双盲研究中，对79例主要患有髋部和膝部骨关节炎的患者进行了研究，比较了舒洛芬和萘普生治疗该疾病症状的疗效和耐受性。药物按每日两次的方案给药：800毫克舒洛芬或750毫克萘普生。在基线以及第7天和第14天评估夜间疼痛、静息痛、运动痛和压痛。结果显示，两组患者在所有参数上均有显著改善。两组之间未发现统计学上的显著差异。因此，舒洛芬在缓解疼痛方面与萘普生一样有效。舒洛芬组有1例患者和萘普生组有2例患者出现轻度胃肠道症状。总体耐受性非常好。
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