• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Chemical synthesis of idiotopes. Evidence that antisera to the same JH1 peptide detect multiple binding site-associated idiotopes.独特型表位的化学合成。针对同一JH1肽的抗血清可检测多个与结合位点相关的独特型表位的证据。
J Exp Med. 1984 May 1;159(5):1338-50. doi: 10.1084/jem.159.5.1338.
2
Hypervariable region peptides variably induce specific anti-idiotypic antibodies: an approach to determining antigenic dominance.高变区肽可不同程度地诱导特异性抗独特型抗体：一种确定抗原优势的方法。
J Immunol. 1986 Jan;136(2):582-7.
3
Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.来自表达A/J品系主要交叉反应独特型的BALB/c小鼠的两种抗对氨基苯砷酸单克隆抗体的重链可变区的完整氨基酸序列。
J Exp Med. 1984 Oct 1;160(4):1070-86. doi: 10.1084/jem.160.4.1070.
4
Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.利用与异常重链多样性基因（DH）、重链连接基因（JH）和κ轻链可变区（Vκ）片段相关的T15重链可变区（VH），从免疫缺陷的CBA/N小鼠中获得的一种磷酸胆碱结合抗体的氨基酸序列。
J Immunol. 1984 Mar;132(3):1544-9.
5
Rat anti-T15 monoclonal antibodies with specificity for VH- and VH-VL epitopes.对VH和VH-VL表位具有特异性的大鼠抗T15单克隆抗体。
Mol Immunol. 1984 Oct;21(10):961-7. doi: 10.1016/0161-5890(84)90154-8.
6
Anti-idiotypic antibodies of a predefined specificity generated against CDR3VH synthetic peptides define a private anti-CD4 idiotype.针对CDR3VH合成肽产生的具有预定特异性的抗独特型抗体定义了一种个体特异性抗CD4独特型。
Mol Immunol. 1990 Jun;27(6):513-22. doi: 10.1016/0161-5890(90)90070-g.
7
Immunologic memory to phosphocholine. IV. Hybridomas representative of Group I (T15-like) and Group II (non-T15-like) antibodies utilize distinct VH genes.对磷酸胆碱的免疫记忆。IV. 代表I组（T15样）和II组（非T15样）抗体的杂交瘤利用不同的VH基因。
J Immunol. 1984 Mar;132(3):1550-5.
8
Influence of the immunoglobulin heavy chain locus on expression of the VK1GAC light chain.免疫球蛋白重链基因座对VK1GAC轻链表达的影响。
J Immunol. 1984 Jul;133(1):465-70.
9
Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype.与人单克隆IgM类风湿因子重链第三高变区相对应的合成肽确定了一个免疫显性独特型。
J Exp Med. 1985 Aug 1;162(2):756-61. doi: 10.1084/jem.162.2.756.
10
Immunochemical and molecular characterization of regulatory idiotopes expressed by monoclonal antibodies exhibiting or lacking beta 2-6 fructosan binding activity.具有或缺乏β2-6果聚糖结合活性的单克隆抗体所表达的调节性独特型表位的免疫化学和分子特征分析
J Exp Med. 1985 Aug 1;162(2):647-62. doi: 10.1084/jem.162.2.647.

引用本文的文献

1
How well can an idiotope peptide mimic replace its parent idiotype in a synthetic peptide vaccine?在合成肽疫苗中，一个独特型表位肽模拟物能在多大程度上替代其亲本独特型？
Pharm Res. 2004 Aug;21(8):1480-8. doi: 10.1023/b:pham.0000036924.01527.f7.
2
Syngeneic antiidiotypic immune responses to a B cell lymphoma. Comparison between heavy chain hypervariable region peptides and intact Ig as immunogens.针对B细胞淋巴瘤的同基因抗独特型免疫反应。重链高变区肽段与完整免疫球蛋白作为免疫原的比较。
J Exp Med. 1985 Jul 1;162(1):19-34. doi: 10.1084/jem.162.1.19.
3
Idiotypic markers of polyclonal B cell activation. Public idiotypes shared by monoclonal antibodies derived from patients with systemic lupus erythematosus or leprosy.多克隆B细胞活化的独特型标志物。系统性红斑狼疮或麻风病患者来源的单克隆抗体所共有的公共独特型。
J Clin Invest. 1987 Feb;79(2):572-81. doi: 10.1172/JCI112849.
4
Antibodies to synthetic joining segment peptide of the T-cell receptor beta-chain: serological cross-reaction between products of T-cell receptor genes, antigen binding T-cell receptors, and immunoglobulins.针对T细胞受体β链合成连接段肽的抗体：T细胞受体基因产物、抗原结合性T细胞受体与免疫球蛋白之间的血清学交叉反应
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1872-6. doi: 10.1073/pnas.83.6.1872.
5
Evolutionary origin of autoreactive determinants (autogens).自身反应性决定簇（自身抗原）的进化起源。
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2521-5. doi: 10.1073/pnas.83.8.2521.

本文引用的文献

1
Individual Antigenic Specificity of Isolated Antibodies.分离抗体的个体抗原特异性
Science. 1963 Jun 14;140(3572):1218-9. doi: 10.1126/science.140.3572.1218.
2
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
3
Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution.完整免疫球蛋白分子Kol及其抗原结合片段在3.0埃和1.0埃分辨率下的晶体学精修与原子模型。
J Mol Biol. 1980 Aug 25;141(4):369-91. doi: 10.1016/0022-2836(80)90252-1.
4
Structural basis for M-173 idiotypic determinants distinctively recognized in syngeneic and allogeneic immunization: contribution of DH, JH, and J kappa regions to an idiotope recognized by allogeneic antisera.在同基因和异基因免疫中特异性识别的M-173独特型决定簇的结构基础：DH、JH和Jκ区域对异基因抗血清识别的一个独特位的贡献。
Ann Immunol (Paris). 1981 Mar-Apr;132C(2):113-29.
5
Structure of a novel Bence-Jones protein (Rhe) fragment at 1.6 A resolution.一种新型本斯-琼斯蛋白（Rhe）片段在1.6埃分辨率下的结构。
J Mol Biol. 1983 Jul 5;167(3):661-92. doi: 10.1016/s0022-2836(83)80104-1.
6
Somatic mutation in a cultured mouse myeloma cell affects antigen binding.培养的小鼠骨髓瘤细胞中的体细胞突变会影响抗原结合。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1240-4. doi: 10.1073/pnas.79.4.1240.
7
Somatic mutation of immunoglobulin light-chain variable-region genes.免疫球蛋白轻链可变区基因的体细胞突变
Cell. 1981 Jul;25(1):47-58. doi: 10.1016/0092-8674(81)90230-0.
8
Organization of four mouse lambda light chain immunoglobulin genes.四个小鼠λ轻链免疫球蛋白基因的组织
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3765-9. doi: 10.1073/pnas.78.6.3765.
9
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.免疫球蛋白重链连接区基因序列及其在抗体多样性产生中的作用。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):509-13. doi: 10.1073/pnas.78.1.509.
10
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.产生完整的免疫球蛋白重链基因需要两种类型的体细胞重组。
Nature. 1980 Aug 14;286(5774):676-83. doi: 10.1038/286676a0.

独特型表位的化学合成。针对同一JH1肽的抗血清可检测多个与结合位点相关的独特型表位的证据。

Chemical synthesis of idiotopes. Evidence that antisera to the same JH1 peptide detect multiple binding site-associated idiotopes.

作者信息

Seiden M V, Clevinger B, McMillan S, Srouji A, Lerner R, Davie J M

出版信息

J Exp Med. 1984 May 1;159(5):1338-50. doi: 10.1084/jem.159.5.1338.

DOI:10.1084/jem.159.5.1338
PMID:6201582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187303/
Abstract

In an attempt to better understand the molecular basis of idiotypy, we have generated several site-specific antisera through immunization of animals with synthetic peptides corresponding to the (JH1) heavy chain joining segment 1 of the mouse heavy chain variable (VH) region. These anti-peptide sera identify several idiotypic determinants present on intact hybridoma and myeloma immunoglobulins. Expression of at least three of these idiotopes is correlated with the antigen specificity of the family of immunoglobulins bearing the determinant. Use of synthetic peptides may prove a powerful technique in the generation of molecularly defined antiidiotypic reagents.

摘要

为了更好地理解个体基因型的分子基础，我们通过用与小鼠重链可变区（VH）的（JH1）重链连接段1相对应的合成肽免疫动物，产生了几种位点特异性抗血清。这些抗肽血清识别完整杂交瘤和骨髓瘤免疫球蛋白上存在的几种个体基因型决定簇。这些个体基因型表位中至少有三种的表达与带有该决定簇的免疫球蛋白家族的抗原特异性相关。合成肽的使用可能被证明是一种在产生分子定义的抗个体基因型试剂方面的强大技术。