Barresi G, Tuccari G
Virchows Arch A Pathol Anat Histopathol. 1984;403(1):59-66. doi: 10.1007/BF00689338.
Using immunoperoxidase procedures, the presence of lactoferrin was investigated in benign hypertrophy (40 cases), differentiated adenocarcinomas (20 cases) and undifferentiated carcinomas (10 cases) of the prostate. In benign hypertrophy, the glandular epithelium and the secretory product were consistently negative. Strong staining for lactoferrin was always observed in neoplastic cells of differentiated adenocarcinomas and in their endoluminal material; in contrast, a very slight positivity was noted in undifferentiated carcinomas. These findings are discussed in relation to the different degree of neoplastic glandular differentiation and functional activity of prostatic carcinomas.
采用免疫过氧化物酶法，对前列腺良性增生（40例）、高分化腺癌（20例）和低分化癌（10例）中乳铁蛋白的存在情况进行了研究。在良性增生中，腺上皮及其分泌产物始终呈阴性。在高分化腺癌的肿瘤细胞及其腔内物质中总是观察到乳铁蛋白的强染色；相比之下，低分化癌中仅观察到非常轻微的阳性。结合前列腺癌不同程度的肿瘤腺分化和功能活性对这些发现进行了讨论。
