Traub W H
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1983 Jul;254(4):480-8.
Three commercial, intravenously applicable human IgG preparations passively protected NMRI mice against intraperitoneal challenge with 11 of 19 selected, serologically defined O-antigen reference strains and clinical, nosocomially significant isolates of Serratia marcescens. Conventional anti-O and anti-H, but not anti-K and anti-protease, rabbit immune sera revealed passive protective capacity against homologous challenge strains; however, anti-O rabbit immune sera failed to invariably protect against heterologous test strains that carried identical serogroup O-antigens. The passive protective efficacy of anti-live cell immune sera, derived from rabbits following recovery from experimental septicemia, was abolished through dual absorption with homologous O-cells. It was concluded that antibodies directed against O-antigens, i.e., lipopolysaccharide moieties, of the challenge strains of S. marcescens afforded passive protection.
三种市售的可静脉注射的人免疫球蛋白制剂被动保护NMRI小鼠，使其免受19种选定的、血清学定义的O抗原参考菌株中的11种以及临床医院感染重要病原菌粘质沙雷氏菌分离株的腹腔攻击。传统的抗O和抗H兔免疫血清，但不是抗K和抗蛋白酶兔免疫血清，显示出对同源攻击菌株的被动保护能力；然而，抗O兔免疫血清未能始终如一地保护免受携带相同血清群O抗原的异源测试菌株的攻击。来自实验性败血症康复后的兔子的抗活细胞免疫血清的被动保护效力，通过与同源O细胞的双重吸收而被消除。得出的结论是，针对粘质沙雷氏菌攻击菌株的O抗原，即脂多糖部分的抗体提供了被动保护。
