Traub W H
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981;249(4):504-11.
A commercially available, intravenously applicable, pepsin-derived human IgG F (ab)2-fragment preparation (Gamma-Venin) revealed O-agglutinin activity against 12 of the 21 currently established O antigens of Serratia marcescens; however, this preparation lacked H-immobilizing antibodies against all 20 H antigens of this microorganism. The addition of 25 vol% of the IgG F (ab)2-fragment preparation of 65 vol% of fresh human serum neither enhanced nor antagonized serum bactericidal activity against selected assay strains of S. marcescens that represented various human serum susceptibility categories. This indifferent effect was obtained despite documented O-agglutinin activity against the O antigens of several of the "delayed-serum sensitive" and "pseudo-serum resistant" assay strains and against the O antigen of a "genuinely serum-resistant" test strain of S. marcescens.
一种市售的、可静脉应用的、源自胃蛋白酶的人IgG F(ab)2片段制剂（γ-毒液）对粘质沙雷氏菌目前确定的21种O抗原中的12种显示出O凝集素活性；然而，该制剂缺乏针对该微生物所有20种H抗原的H固定抗体。添加65%新鲜人血清中25%体积的IgG F(ab)2片段制剂，对代表不同人血清敏感性类别的选定粘质沙雷氏菌检测菌株，既未增强也未拮抗血清杀菌活性。尽管有记录表明该制剂对几种“延迟血清敏感”和“假血清抗性”检测菌株的O抗原以及对粘质沙雷氏菌“真正血清抗性”测试菌株的O抗原具有O凝集素活性，但仍得到这种无明显作用的效果。
