Traub W H
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981;250(1-2):84-91.
A commercial, low pH-derived, intravenously applicable human IgG immunoglobulin preparation (Sandoglobulin) revealed O-agglutinin activity against 16 of the 21 O-antigens of Serratia marcescens, although at low titers; this IgG preparation lacked H-immobilizing antibodies against this microorganism. The bactericidal activity of 65 vol% of normal, fresh human serum was neither enhanced nor significantly antagonized following addition of 25 vol% of undiluted or 1:4 diluted. Sandoglobulin, as determined with test strains of S. marcescens that represented various human serum susceptibility categories. This indifferent effect was obtained despite documented O-agglutinin activity directed against several of the assay strains. It was concluded tentatively, that human, "natural" anti- S. marcescens IgG antibodies failed to augment human serum bactericidal activity in vitro against this opportunistic-pathogenic microorganism.
一种市售的、低pH值来源的、可静脉注射的人IgG免疫球蛋白制剂（Sandoglobulin）显示出针对粘质沙雷氏菌21种O抗原中的16种的O凝集素活性，尽管效价较低；这种IgG制剂缺乏针对该微生物的H固定抗体。添加25%未稀释或1:4稀释的Sandoglobulin后，65%体积的正常新鲜人血清的杀菌活性既未增强也未受到显著拮抗，这是用代表各种人血清敏感性类别的粘质沙雷氏菌测试菌株测定的。尽管有记录表明针对几种检测菌株有O凝集素活性，但仍得到这种无影响的结果。初步得出结论，人“天然”抗粘质沙雷氏菌IgG抗体在体外未能增强人血清对这种机会致病性微生物的杀菌活性。
