Mioduszewski J Z, Halski L, Mioduszewska M
Arch Immunol Ther Exp (Warsz). 1983;31(5):663-8.
Three new derivatives of dextran were obtained: 3-morpholine-2-hydroxypropyl ether of dextran (I), hydroxamic acid of carboxymethyl dextran (II), and oxime of ketodextran (III). All the three derivatives exhibited low toxicity at parenteral administration to laboratory animals. (I) and (II) showed the capability of weakening the activity of tetanus and malignant edema toxins. Additionally, (I) showed immunotropic activity. Biological activity was observed when the derivative (I) had been obtained from dextran of the molecular weight 4000. At the molecular weight 20,000 the activity did not appear. Similarly, no activity was observed under oral administration.
葡聚糖3-吗啉-2-羟丙基醚（I）、羧甲基葡聚糖异羟肟酸（II）和酮葡聚糖肟（III）。这三种衍生物经肠胃外给药于实验动物时均表现出低毒性。（I）和（II）显示出减弱破伤风毒素和恶性水肿毒素活性的能力。此外，（I）表现出免疫otropic活性。当衍生物（I）由分子量为4000的葡聚糖制得时观察到了生物活性。分子量为20000时未出现活性。同样，口服给药时未观察到活性。
