Wieczorek Z, Giełdanowski J, Zimecki M, Skibiński G, Mioduszewski J Z
Arch Immunol Ther Exp (Warsz). 1983;31(5):677-89.
The immunobiological investigations of H-2 preparation--a modified derivative of DEAE dextran--revealed that the preparation has a wide immunotropic spectrum with the predominance of the stimulatory effect. It stimulates the I and II humoral immunological responses to SRBC. It stimulates the induction and effector processes of the cellular type reactions. Under the in vivo and in vitro conditions it causes mouse precursor T cells to gain the theta antigen. On the other hand, H-2 preparation suppresses the development of GvH reaction induced either by the administration of cells coming from the donor treated with the preparation (in vivo), or by the incubation of the donor's cells with the compound under examination. H-2 preparation is non-toxic, and does not exhibit any antiviral or interferogenic activity.
对H-2制剂（一种改良的DEAE葡聚糖衍生物）的免疫生物学研究表明，该制剂具有广泛的免疫调节谱，且以刺激作用为主。它能刺激对绵羊红细胞的I型和II型体液免疫反应。它能刺激细胞型反应的诱导和效应过程。在体内和体外条件下，它能使小鼠前体T细胞获得θ抗原。另一方面，H-2制剂可抑制移植物抗宿主反应的发展，这种反应可由给予用该制剂处理过的供体的细胞（体内）或供体细胞与受试化合物孵育诱导产生。H-2制剂无毒，且不表现出任何抗病毒或干扰素生成活性。
