Wieczorek Z, Giełdanowski J, Zimecki M, Skibiński G, Mioduszewski J Z
Arch Immunol Ther Exp (Warsz). 1983;31(5):691-700.
The immunological investigations were carried out on mice with the aim to determine the immunotropic properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79), a derivative of previously described 3-morpholine-2-hydroxypropyl ether of dextran (H-2). In the examinations of the copper complex also the H-2 preparation was applied, and for comparative purposes--levamisol, a popular stimulator of immunological responses. It was stated that C-79 similarly to H-2 and levamisol, stimulated the humoral and cellular anti-SRBC immunological responses. Moreover, it increased the number of cells producing anti-H-B antibodies, stimulated the appearance of thy-1,2 antigen on the precursor T cells and inhibited the in vivo and in vitro GvH reactions. H-2 and C-79 preparations intensified the effect of the inductor of the Poli I:C.
对小鼠进行了免疫学研究，目的是确定二价铜与葡聚糖的3-巯基-2-羟丙基醚（C-79）的复合物的免疫趋向特性，C-79是先前描述的葡聚糖的3-吗啉代-2-羟丙基醚（H-2）的衍生物。在对铜复合物的检测中也应用了H-2制剂，并且为了进行比较——还使用了左旋咪唑，一种常用的免疫反应刺激剂。结果表明，C-79与H-2和左旋咪唑类似，刺激了体液和细胞抗SRBC免疫反应。此外，它增加了产生抗H-B抗体的细胞数量，刺激了前体T细胞上thy-1,2抗原的出现，并抑制了体内和体外的移植物抗宿主反应。H-2和C-79制剂增强了聚肌苷酸:聚胞苷酸（Poli I:C）诱导剂的作用。
