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二价铜与葡聚糖的3-巯基-2-羟丙基醚复合物(C-79)的辐射防护活性

Radioprotective activity of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79).

作者信息

Wieczorek Z, Giełdanowski J, Zimecki M, Mioduszewski J Z, Szymaniec S, Daczyńska R

出版信息

Arch Immunol Ther Exp (Warsz). 1983;31(5):715-29.

PMID:6202277
Abstract

The radioprotective activity of C-79 preparation was determined in the course of investigations carried out on mice. The activity was measured by the survival time of lethally irradiated animals and by means of the number of colonies (CFUs) on the spleens of irradiated animals. The endogenous and exogenous CFUs were determined. It was stated that the preparation, when introduced into animals several days before the irradiation with an appropriate dose of X rays, protected the homeopoetic cells of the examined animals against the irradiation effects. It was also revealed that the preparation significantly prolonged the survival time of the lethally irradiated mice. The protection activity of the preparation depended on the dose and the strategy of administration.

摘要

在对小鼠进行的研究过程中测定了C-79制剂的辐射防护活性。通过受致死剂量照射动物的存活时间以及照射动物脾脏上的集落(CFU)数量来衡量该活性。测定了内源性和外源性CFU。结果表明,在以适当剂量的X射线照射动物前几天将该制剂引入动物体内时,可保护受试动物的造血细胞免受辐射影响。还发现该制剂显著延长了受致死剂量照射小鼠的存活时间。该制剂的保护活性取决于剂量和给药策略。

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Radioprotective activity of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79).二价铜与葡聚糖的3-巯基-2-羟丙基醚复合物(C-79)的辐射防护活性
Arch Immunol Ther Exp (Warsz). 1983;31(5):715-29.
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