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黑质中乙酰胆碱酯酶的非胆碱能功能：行为学证据。

A non-cholinergic function for acetylcholinesterase in the substantia nigra: behavioural evidence.

作者信息

Greenfield S A, Chubb I W, Grünewald R A, Henderson Z, May J, Portnoy S, Weston J, Wright M C

出版信息

Exp Brain Res. 1984;54(3):513-20. doi: 10.1007/BF00235476.

DOI:10.1007/BF00235476
PMID:6202543
Abstract

Acetylcholinesterase is released from substantia nigra neurons, independently of cholinergic transmission. In an attempt to discover the functional significance of this phenomenon, the behavioural effects of injecting acetylcholinesterase into one substantia nigra of the rat were investigated. Following a single injection of the enzyme, intraperitoneal amphetamine evoked circling behaviour in a direction away from the side of injection. Purified acetylcholinesterase with a similar electrophoretic mobility to the endogenous secreted form, was far more potent in eliciting circling than much higher activities of commercial enzyme, consisting of several molecular species of acetylcholinesterase. Similar infusions of butyrylcholinesterase did not induce circling. Depending upon the amount of enzyme initially given, the behavioural effects of a single injection of acetylcholinesterase persisted for up to thirty days. During this period apomorphine, administered systemically, induced transient circling towards the acetylcholinesterase-treated side. It is concluded that secreted acetylcholinesterase has a functional significance within the substantia nigra, independent of cholinergic transmission. This released enzyme could exert long-term changes in the activity of the nigrostriatal system, involving modification of dopamine striatal receptors.

摘要

乙酰胆碱酯酶从黑质神经元释放，与胆碱能传递无关。为了探究这一现象的功能意义，研究了向大鼠一侧黑质注射乙酰胆碱酯酶的行为效应。单次注射该酶后，腹腔注射苯丙胺会诱发大鼠向远离注射侧的方向转圈行为。与内源性分泌形式具有相似电泳迁移率的纯化乙酰胆碱酯酶，在引发转圈行为方面比活性高得多的市售酶（由几种分子形式的乙酰胆碱酯酶组成）更有效。类似地注射丁酰胆碱酯酶不会诱发转圈行为。根据最初给予的酶量，单次注射乙酰胆碱酯酶的行为效应可持续长达30天。在此期间，全身给予阿扑吗啡会诱发短暂的向乙酰胆碱酯酶处理侧的转圈行为。结论是，分泌的乙酰胆碱酯酶在黑质内具有功能意义，与胆碱能传递无关。这种释放的酶可能会使黑质纹状体系统的活性发生长期变化，涉及多巴胺纹状体受体的修饰。

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Acetylcholinesterase has a non-cholinergic neuromodulatory action in the guinea-pig substantia nigra.乙酰胆碱酯酶在豚鼠黑质中具有非胆碱能神经调节作用。
Exp Brain Res. 1987;67(2):445-8. doi: 10.1007/BF00248567.
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Comparison of butyrylcholinesterase and acetylcholinesterase.丁酰胆碱酯酶与乙酰胆碱酯酶的比较。
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A noncholinergic action of acetylcholinesterase (AChE) in the brain: from neuronal secretion to the generation of movement.乙酰胆碱酯酶（AChE）在大脑中的非胆碱能作用：从神经元分泌到运动的产生。
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Evoked release of proteins from central neurons in vivo.体内中枢神经元蛋白质的诱发释放。
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Psychopharmacology (Berl). 1982;76(3):294-8. doi: 10.1007/BF00432565.
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Origin of various enzymes released from the substantia nigra and caudate nucleus: effects of 6-hydroxydopamine lesions of the nigro-striatal pathway.黑质和尾状核释放的各种酶的来源：黑质纹状体通路6-羟基多巴胺损伤的影响。
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