实验性小鼠沙门氏菌病中保护性抗沙门氏菌抗体的同种型
Isotype of protective anti-Salmonella antibodies in experimental mouse salmonellosis.
作者信息
Saxén H, Mäkelä O, Svenson S B
出版信息
Infect Immun. 1984 Jun;44(3):633-6. doi: 10.1128/iai.44.3.633-636.1984.
Abstract
Mice and a rabbit were immunized with heat-killed Salmonella typhimurium bacteria or with an O-4,12 antigen-specific octasaccharide-protein conjugate. Immunoglobulin isotypes of the antisera were tested for their capacity to protect mice against experimental salmonellosis. Antibodies of immunoglobulin M + A isotypes were more protective than the immunoglobulin G antibodies in each of the two pools of mouse sera. The same protective pattern was also seen with a rabbit antiserum elicited by the artificial octasaccharide-protein conjugate, i.e., with antibodies with the exclusive specificity for the O-4,12 antigen determinants of S. typhimurium.
摘要
用热灭活的鼠伤寒沙门氏菌或O-4,12抗原特异性八糖-蛋白质偶联物对小鼠和兔子进行免疫。检测抗血清的免疫球蛋白同种型保护小鼠抵抗实验性沙门氏菌病的能力。在两组小鼠血清中，免疫球蛋白M+A同种型的抗体比免疫球蛋白G抗体具有更强的保护作用。在用人工合成的八糖-蛋白质偶联物诱导产生的兔抗血清中也观察到相同的保护模式，即对鼠伤寒沙门氏菌O-4,12抗原决定簇具有特异性的抗体。
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