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对源自马立克氏病淋巴瘤的鸡细胞系MSB1中含N-羟乙酰神经氨酸的糖鞘脂进行表征，作为肿瘤相关嗜异性汉-迪抗原。

Characterization of N-glycolyneuraminic acid-containing glycosphingolipids from a Marek's disease lymphoma-derived chicken cell line, MSB1, as tumor-associated heterophile Hanganutziu-Deicher antigens.

作者信息

Higashi H, Ikuta K, Ueda S, Kato S, Hirabayashi Y, Matsumoto M, Naiki M

出版信息

J Biochem. 1984 Mar;95(3):785-94. doi: 10.1093/oxfordjournals.jbchem.a134670.

DOI:10.1093/oxfordjournals.jbchem.a134670
PMID:6202681
Abstract

Heterophile, Hanganutziu-Deicher (HD) antigen-active N-glycolylneuraminic acid-containing glycosphingolipids (GSLs) were detected as tumor-associated foreign antigens of a Marek's disease lymphoma-derived cell line, MSB1, by enzyme-immunoassay with chicken antibody against N-glycolylneuraminyl-lactosylceramide (anti-NeuGc-LacCer). At least three species of HD antigen-active GSLs were detected by two-dimensional thin-layer chromatography (TLC) combined with enzyme-immunoassay. The reactivities of the GSLs with anti-NeuGc-LacCer, their behaviors on two-dimensional TLC and the results of an endo-beta-galactosidase digestion study indicated that these three GSLs were NeuGc-LacCer (NeuGc alpha 2-2Gal beta 1-4Glc-Cer), NeuGc-nLcOse4Cer (NeuGc alpha 2-3Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc-Cer) and NeuGc-nLcOse6Cer (NeuGc alpha 2-3Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc-Cer).

摘要

通过用抗N - 羟乙酰神经氨酸乳糖神经酰胺（抗NeuGc - LacCer）的鸡抗体进行酶免疫测定，在马立克氏病淋巴瘤衍生细胞系MSB1中，检测到嗜异性、汉加努齐乌 - 戴歇尔（HD）抗原活性的含N - 羟乙酰神经氨酸的糖鞘脂（GSLs）作为肿瘤相关的外来抗原。通过二维薄层色谱（TLC）结合酶免疫测定，检测到至少三种HD抗原活性的GSLs。这些GSLs与抗NeuGc - LacCer的反应性、它们在二维TLC上的行为以及内切β - 半乳糖苷酶消化研究的结果表明，这三种GSLs分别是NeuGc - LacCer（NeuGcα2 - 2Galβ1 - 4Glc - Cer）、NeuGc - nLcOse4Cer（NeuGcα2 - 3Galβ1 - 4GlcNAcβ1 - 3Galβ1 - 4Glc - Cer）和NeuGc - nLcOse6Cer（NeuGcα2 - 3Galβ1 - 4GlcNAcβ1 - 3Galβ1 - 4GlcNAcβ1 - 3Galβ1 - 4Glc - Cer）。

相似文献

1
Characterization of N-glycolyneuraminic acid-containing glycosphingolipids from a Marek's disease lymphoma-derived chicken cell line, MSB1, as tumor-associated heterophile Hanganutziu-Deicher antigens.对源自马立克氏病淋巴瘤的鸡细胞系MSB1中含N-羟乙酰神经氨酸的糖鞘脂进行表征，作为肿瘤相关嗜异性汉-迪抗原。
J Biochem. 1984 Mar;95(3):785-94. doi: 10.1093/oxfordjournals.jbchem.a134670.
2
Sensitive enzyme-immunostaining and densitometric determination on thin-layer chromatography of N-glycolylneuraminic acid-containing glycosphingolipids, Hanganutziu-Deicher antigens.含N-羟乙酰神经氨酸的糖鞘脂（汉努齐乌-戴歇尔抗原）的薄层色谱上的敏感酶免疫染色及光密度测定。
J Biochem. 1984 May;95(5):1517-20. doi: 10.1093/oxfordjournals.jbchem.a134760.
3
Occurrence of tumor-associated ganglioside antigens with Hanganutziu-Deicher antigenic activity on human melanomas.人类黑色素瘤上具有汉努齐乌-戴歇尔抗原活性的肿瘤相关神经节苷脂抗原的出现情况。
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Specific expression of unusual GM2 ganglioside with Hanganutziu-Deicher antigen activity on human colon cancers.具有汉根纽齐乌-戴歇尔抗原活性的异常GM2神经节苷脂在人类结肠癌上的特异性表达。
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Quantitative determination of N-glycolylneuraminic acid expression in human cancerous tissues and avian lymphoma cell lines as a tumor-associated sialic acid by gas chromatography-mass spectrometry.通过气相色谱-质谱联用法定量测定人癌组织和禽淋巴瘤细胞系中作为肿瘤相关唾液酸的N-羟乙酰神经氨酸表达。
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Identification of N-glycolylneuraminic acid-containing gangliosides of cat and sheep erythrocytes. 252Cf fission fragment ionization mass spectrometry in the analysis of glycosphingolipids.猫和绵羊红细胞中含N-羟乙酰神经氨酸神经节苷脂的鉴定。252Cf裂变碎片电离质谱法在糖鞘脂分析中的应用。
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Two chicken monoclonal antibodies specific for heterophil Hanganutziu-Deicher antigens.两种对嗜异性汉氏-德氏抗原具有特异性的鸡单克隆抗体。
Immunol Lett. 1992 Mar;32(1):91-6. doi: 10.1016/0165-2478(92)90205-3.
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Hanganutziu and Deicher type heterophile antigen expressed on the cell surface of Marek's disease lymphoma-derived cell lines.马立克氏病淋巴瘤来源的细胞系细胞表面表达的汉氏（Hanganutziu）和戴氏（Deicher）嗜异性抗原
Biken J. 1981 Jun;24(1-2):23-37.
10
Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer.含N-羟乙酰神经氨酸神经节苷脂作为人结肠癌中肿瘤相关的汉努齐乌-戴歇尔抗原的特性分析
Cancer Res. 1985 Aug;45(8):3796-802.

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