Huang S C, Chen H C, Kurman R J, Yang Y S, Wen H K, Hsieh C Y, Wei P Y, How S W, Chen T Y, Ouyang P C
Gynecol Oncol. 1984 Jun;18(2):240-6. doi: 10.1016/0090-8258(84)90032-5.
alpha-Fetoprotein (alpha FP) and four placental proteins, human chorionic gonadotropin (hCG), human placental lactogen (hpL), pregnancy specific beta 1-glycoprotein (SP1), and placental protein 5 (PP5), were measured in a 17-year-old patient with endodermal sinus tumor of the ovary. The circulating levels of alpha FP were consistently high (more than 14 mg/ml), and alpha FP was localized in tissue sections using immunohistochemical techniques. None of the four placental proteins was detectable in serum samples, but hCG was detected in urinary concentrates in an episodic manner. This ectopic hCG resembled placental hCG in its physicochemical and immunological characteristics. Unlike alpha FP, hCG was not detected in the tumor by immunohistochemical methods. This study indicates that the neoplasm elaborated both hCG and alpha FP. Whether pure endodermal sinus tumor of the ovary is capable of secreting hCG cannot be answered by this study because of limited histologic sampling. The likelihood that this represents a mixed germ cell tumor in which only the endodermal sinus tumor element was sampled remains a possibility. This study also indicates that the 24-hr urinary concentrate is far more sensitive than serum samples for hCG detection.
对一名17岁患有卵巢内胚窦瘤的患者检测了甲胎蛋白（αFP）和四种胎盘蛋白，即人绒毛膜促性腺激素（hCG）、人胎盘催乳素（hpL）、妊娠特异性β1-糖蛋白（SP1）和胎盘蛋白5（PP5）。甲胎蛋白的循环水平持续偏高（超过14mg/ml），并采用免疫组织化学技术在组织切片中定位甲胎蛋白。血清样本中未检测到四种胎盘蛋白中的任何一种，但在尿浓缩物中偶尔检测到hCG。这种异位hCG在物理化学和免疫学特性上类似于胎盘hCG。与甲胎蛋白不同，免疫组织化学方法在肿瘤中未检测到hCG。本研究表明，该肿瘤同时产生hCG和甲胎蛋白。由于组织学取样有限，本研究无法回答卵巢单纯性内胚窦瘤是否能够分泌hCG的问题。这有可能代表一种混合性生殖细胞肿瘤，其中仅对其进行取样的是内胚窦瘤成分。本研究还表明，24小时尿浓缩物对hCG检测的敏感性远高于血清样本。
