Dellagi K, Brouet J C, Portier M M, Lenoir G M
J Natl Cancer Inst. 1984 Jul;73(1):95-100.
The expression of vimentin, the major polypeptide of the intermediate filament (IFM) cytoskeleton of lymphoid cells, was studied in normal and malignant human lymphoid cell lines. Cells from 24 of 27 Burkitt's lymphoma cell lines (BLCL) were found to have an absent (16 lines) or decreased (8 lines) expression of vimentin IFM. In contrast, non-Burkitt's malignant lymphoid cell lines (5 lines) and lymphoblastoid cell lines (LCL) derived from normal B-cells (45 lines) exhibited a well-developed vimentin IFM network. However, low expression of vimentin was also found in 3 LCL derived from patients with the Langer-Giedion syndrome, which is characterized by a deletion of the distal end of chromosome 8. Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin.
在正常和恶性人类淋巴细胞系中，研究了波形蛋白（淋巴细胞中间丝（IFM）细胞骨架的主要多肽）的表达情况。在27个伯基特淋巴瘤细胞系（BLCL）中，有24个细胞系的波形蛋白IFM表达缺失（16个细胞系）或降低（8个细胞系）。相比之下，非伯基特恶性淋巴细胞系（5个细胞系）和源自正常B细胞的淋巴母细胞系（LCL，45个细胞系）呈现出发育良好的波形蛋白IFM网络。然而，在3个源自患有朗格-吉迪恩综合征（以8号染色体远端缺失为特征）患者的LCL中也发现了波形蛋白的低表达。用氮杂胞苷处理波形蛋白阴性的BLCL和朗格-吉迪恩LCL会导致波形蛋白的短暂重新表达。
