Sodroski J, Patarca R, Perkins D, Briggs D, Lee T H, Essex M, Coligan J, Wong-Staal F, Gallo R C, Haseltine W A
Science. 1984 Jul 27;225(4660):421-4. doi: 10.1126/science.6204380.
The sequence of the envelope glycoprotein gene of type II human T lymphotropic virus (HTLV) is presented. The predicted amino acid sequence is similar to that of the corresponding protein of HTLV type I, in that the proteins share the same amino acids at 336 of 488 residues, and 68 of the 152 differences are of a conservative nature. The overall structural similarity of these proteins provides an explanation for the antigenic cross-reactivity observed among diverse members of the HTLV retrovirus family by procedures that assay for the viral envelope glycoprotein, for example, membrane immunofluorescence.
本文展示了II型人类嗜T淋巴细胞病毒（HTLV）包膜糖蛋白基因的序列。预测的氨基酸序列与I型HTLV相应蛋白的序列相似，在488个残基中有336个氨基酸相同，152个差异中的68个是保守性的。这些蛋白质的整体结构相似性解释了通过检测病毒包膜糖蛋白的方法（例如膜免疫荧光）在HTLV逆转录病毒家族不同成员之间观察到的抗原交叉反应性。
