绵羊胃黏蛋白作为血型I和i抗原的来源。
Sheep gastric mucins as a source of blood-group-I and -i antigens.
作者信息
Wood E, Hounsell E F, Langhorne J, Feizi T
出版信息
Biochem J. 1980 Jun 1;187(3):711-8. doi: 10.1042/bj1870711.
Abstract
Gastric-mucosal glycoproteins of sheep have been shown to express the blood-group-I and -i antigens. The highest blood-group-I activities were found in glycoproteins lacking in blood-group-A and -H activities. In antigenically very active glycoprotein preparations, approx. 25% of the macromolecules expressed various blood-group-I and -i antigens, and these could be enriched by affinity chromatography with an anti-(blood group I) immunoadsorbent column. Additional blood-group-I and -i activities could be revealed by one cycle of Smith degradation of blood-group-A-active sheep gastric glycoproteins. Thus sheep gastric mucins are an abundant source of oligosaccharides with blood-group-I- and -i-active sequences.
摘要
已证明绵羊胃黏膜糖蛋白表达血型I和i抗原。在缺乏血型A和H活性的糖蛋白中发现了最高的血型I活性。在抗原活性非常高的糖蛋白制剂中，约25%的大分子表达了各种血型I和i抗原，并且这些抗原可以通过用抗（血型I）免疫吸附柱进行亲和层析来富集。血型A活性绵羊胃糖蛋白经一轮史密斯降解后可显示出额外的血型I和i活性。因此，绵羊胃黏液是具有血型I和i活性序列的寡糖的丰富来源。
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