Emson P C, Gilbert R F, Martensson H, Nobin A
Cancer. 1984 Aug 15;54(4):715-8. doi: 10.1002/1097-0142(1984)54:4<715::aid-cncr2820540420>3.0.co;2-6.
Ten patients with metastatic carcinoid tumors in the liver showed elevated 5-hydroxytryptamine and substance P levels in plasma samples taken from hepatic or peripheral veins. Chromatographic characterization of the substance P-immunoreactivity showed that by gel permeation and high pressure liquid chromatography the substance P-immunoreactivity was indistinguishable from synthetic undecapeptide substance P. The results suggest that substance P, in addition to the 5-hydroxyinoles, may serve as a circulatory marker for some forms of carcinoid tumors.
