Wagnerová M, Wagner V, Znojemská S, Hrebacka J
Regional Hygienic Station, Middle Bohemia Region, Prague, Czechoslovakia.
J Hyg Epidemiol Microbiol Immunol. 1988;32(3):265-72.
Serum samples were assayed in 110 workers (59 smokers and 51 non-smokers) at PVC manufacturing factory, the results being compared with those obtained in a group of age-matched healthy controls. Non-smokers had significantly higher levels of immunoglobulins (IgG, IgA, IgM), while in smokers there was an increase in IgM only. Lysozyme levels (LYS) were elevated in all exposed subjects, but there was a highly significant decrease in the total protein (TP) content. Alfa-2-macroglobulin (A2M) and orosomucoid (ORO) were also elevated in exposed workers. A significant increase was found in ceruloplasmin (CPL), with smokers having higher levels than non-smokers. No difference was detected between the examined groups in transferrin (TRF) and alfa-1-antitrypsin (A1AT). Exposure duration did not correlate with any of the assayed parameters. The positive correlation of IgA levels and inverse correlation of CPL with age in the control group could not be confirmed in the exposed subjects where a significant inverse correlation between age and AlAT levels, which was found to be positive in exposed non-smokers, proved to be inverse in the subgroup of smokers. The authors discuss possible explanations of the reported findings.
对一家聚氯乙烯制造工厂的110名工人（59名吸烟者和51名非吸烟者）的血清样本进行了检测，并将结果与一组年龄匹配的健康对照者的结果进行了比较。非吸烟者的免疫球蛋白（IgG、IgA、IgM）水平显著更高，而吸烟者仅IgM有所增加。所有接触者的溶菌酶水平（LYS）均升高，但总蛋白（TP）含量显著降低。接触工人的α-2-巨球蛋白（A2M）和类粘蛋白（ORO）也升高。铜蓝蛋白（CPL）显著增加，吸烟者的水平高于非吸烟者。在转铁蛋白（TRF）和α-1-抗胰蛋白酶（A1AT）方面，各检测组之间未检测到差异。接触持续时间与任何检测参数均无相关性。对照组中IgA水平与年龄的正相关以及CPL与年龄的负相关在接触者中未得到证实，在接触者中，年龄与AlAT水平之间存在显著的负相关，这在接触的非吸烟者中为正相关，在吸烟者亚组中则为负相关。作者讨论了所报告结果的可能解释。
