Duquesnoy R J, Marrari M, Hackbarth S, Zeevi A
Hum Immunol. 1984 Jul;10(3):165-76. doi: 10.1016/0198-8859(84)90037-5.
A new serological HLA-DR associated determinant was defined by a cluster of six B cell alloantisera. This determinant, designated as MC1, was strongly associated with DR1 and DR4 and appeared unrelated to MB, MT, and SB. The antigen frequency of MC1 was 47% in Caucasoids and 43% in Blacks. Mixed leukocyte culture cloning yielded an alloreactive T cell clone with PLT specificity associated with MC1. We have also observed that certain alloreactive clones may also acquire expression of MC1 but not DR4 during long-term culture maintenance in the presence of DR4, MC1-positive feeder cells. Disease association studies showed a significantly increased frequency of MC1 in adult rheumatoid arthritis patients (93.5% vs 47.4% in normals; relative risk 16.1). These findings suggest that MC1 represents a novel HLA-D encoded determinant.
一种新的血清学 HLA - DR 相关决定簇由一组六种 B 细胞同种抗血清所定义。这个决定簇被命名为 MC1，它与 DR1 和 DR4 密切相关，而似乎与 MB、MT 和 SB 无关。MC1 的抗原频率在白种人中为 47%，在黑人中为 43%。混合淋巴细胞培养克隆产生了一个具有与 MC1 相关的 PLT 特异性的同种反应性 T 细胞克隆。我们还观察到，在存在 DR4、MC1 阳性饲养细胞的情况下进行长期培养维持时，某些同种反应性克隆可能也会获得 MC1 的表达，但不会获得 DR4 的表达。疾病关联研究表明，成年类风湿性关节炎患者中 MC1 的频率显著增加（93.5% 对比正常人群中的 47.4%；相对风险 16.1）。这些发现表明 MC1 代表一种新的 HLA - D 编码决定簇。
